Risk factors and survival analysis of haemodialysis complicated with infective endocarditis

The clinical features and risk factors for survival time were analysed in haemodialysis patients complicated with infective endocarditis. A total of 101 infective endocarditis (IE) patients treated at Hangzhou First People's Hospital, from January 1, 2012, to April 1, 2022, were included in the...

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Published in:Experimental and therapeutic medicine 2023-05, Vol.25 (5), Article 203
Main Authors: He, Ya-Jing, Ye, Cun-Si, Xu, Ke-Yang, Yang, Li-Li, Wang, Kai-Le, Wang, Xiao-Mei, Li, Mei-Yu, Wu, Yu, Ying, Qi-Su, Wang, Ming, Quan, Shi-Jian, Yang, Xiu
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Language:English
Subjects:
Anemia
Blood
Calcification
Cardiovascular disease
Cholesterol
Diabetes
Ejection fraction
Endocarditis
Heart
Hemodialysis
Hemoglobin
Kidney diseases
Leukocytes
Medical prognosis
Normal distribution
Pathogens
Patients
Proteins
Risk factors
Staphylococcus infections
Statistical analysis
Survival analysis
Triglycerides
Vegetation
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container_issue 5
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container_title Experimental and therapeutic medicine
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creator He, Ya-Jing
Ye, Cun-Si
Xu, Ke-Yang
Yang, Li-Li
Wang, Kai-Le
Wang, Xiao-Mei
Li, Mei-Yu
Wu, Yu
Ying, Qi-Su
Wang, Ming
Quan, Shi-Jian
Yang, Xiu
description The clinical features and risk factors for survival time were analysed in haemodialysis patients complicated with infective endocarditis. A total of 101 infective endocarditis (IE) patients treated at Hangzhou First People's Hospital, from January 1, 2012, to April 1, 2022, were included in the present study. Baseline demographic data and laboratory data were collected for statistical analysis of risk factors and survival time in the IE with haemodialysis group (HD-IE group, n=15) and the IE without haemodialysis group (NHD-IE group, n=86). Haemoglobin, red blood cells, C-reactive protein, procalcitonin, serum albumin, diabetes, invasive procedures, positive blood bacteria culture, heart valve calcification ratio, and left ventricular ejection fraction level were risk factors for infective endocarditis complicated with haemodialysis (P
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A total of 101 infective endocarditis (IE) patients treated at Hangzhou First People's Hospital, from January 1, 2012, to April 1, 2022, were included in the present study. Baseline demographic data and laboratory data were collected for statistical analysis of risk factors and survival time in the IE with haemodialysis group (HD-IE group, n=15) and the IE without haemodialysis group (NHD-IE group, n=86). Haemoglobin, red blood cells, C-reactive protein, procalcitonin, serum albumin, diabetes, invasive procedures, positive blood bacteria culture, heart valve calcification ratio, and left ventricular ejection fraction level were risk factors for infective endocarditis complicated with haemodialysis (P&lt;0.05). Compared with the NHD-IE group, the HD-IE group had an obviously increased risk of mortality (χ2=6.323, P=0.012). The univariate Cox regression analysis showed that age, haemoglobin, red blood cells, serum albumin, left ventricular ejection score, longest vegetation diameter, combined hypotension and diabetes were risk factors for death; furthermore, multivariate Cox regression showed that age (HR=1.187, P=0.015), combined hypotension (HR=0.921, P=0.025) and the longest vegetation diameter (HR=9.191, P=0.004) were independent risk factors affecting the survival of patients. Collectively, the present study revealed that the mortality rate of HD-IE patients was higher than that of NHD-IE patients. Older age, hypotension, and the longest vegetation diameter were independent risk factors affecting the survival of patients. 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The univariate Cox regression analysis showed that age, haemoglobin, red blood cells, serum albumin, left ventricular ejection score, longest vegetation diameter, combined hypotension and diabetes were risk factors for death; furthermore, multivariate Cox regression showed that age (HR=1.187, P=0.015), combined hypotension (HR=0.921, P=0.025) and the longest vegetation diameter (HR=9.191, P=0.004) were independent risk factors affecting the survival of patients. Collectively, the present study revealed that the mortality rate of HD-IE patients was higher than that of NHD-IE patients. Older age, hypotension, and the longest vegetation diameter were independent risk factors affecting the survival of patients. 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The univariate Cox regression analysis showed that age, haemoglobin, red blood cells, serum albumin, left ventricular ejection score, longest vegetation diameter, combined hypotension and diabetes were risk factors for death; furthermore, multivariate Cox regression showed that age (HR=1.187, P=0.015), combined hypotension (HR=0.921, P=0.025) and the longest vegetation diameter (HR=9.191, P=0.004) were independent risk factors affecting the survival of patients. Collectively, the present study revealed that the mortality rate of HD-IE patients was higher than that of NHD-IE patients. Older age, hypotension, and the longest vegetation diameter were independent risk factors affecting the survival of patients. For HD-IE patients, active and effective antibiotic treatment or surgical treatment should be strongly recommended.</abstract><cop>Athens</cop><pub>Spandidos Publications UK Ltd</pub><doi>10.3892/etm.2023.11902</doi><oa>free_for_read</oa></addata></record>
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subjects Anemia
Blood
Calcification
Cardiovascular disease
Cholesterol
Diabetes
Ejection fraction
Endocarditis
Heart
Hemodialysis
Hemoglobin
Kidney diseases
Leukocytes
Medical prognosis
Normal distribution
Pathogens
Patients
Proteins
Risk factors
Staphylococcus infections
Statistical analysis
Survival analysis
Triglycerides
Vegetation
title Risk factors and survival analysis of haemodialysis complicated with infective endocarditis
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