The possible haematological effects of glycol monomethyl ether in a frame factory

Haemopoietic effects of ethylene glycol monomethyl ether (EGME) are described in three young women employed in a frame factory where the substance was applied under apparently safe hygienic conditions. In a ventilated room they used a mixture of acetone (70%) and EGME (30%) to glue together cellulos...

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Bibliographic Details
Published in:British Journal of Industrial Medicine 1992-02, Vol.49 (2), p.131-133
Main Authors: Larese, F, Fiorito, A, De Zotti, R
Format: Article
Language:English
Subjects:
Adult
Anemia, Macrocytic - chemically induced
Anemia, Macrocytic - pathology
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Chemical hazards
Ethers
Ethylene Glycols - adverse effects
Female
Glycols
Hematopoietic System - drug effects
Humans
Industrial hygiene
Leukocyte Count
Leukocytes
Leukopenia - chemically induced
Leukopenia - pathology
Lymphocytes
Lymphocytes - pathology
Medical sciences
Occupational Diseases - chemically induced
Occupational Diseases - pathology
Occupational Exposure - adverse effects
Poisoning
Skin Absorption - physiology
Solvents
Solvents - adverse effects
Toxicity
Toxicology
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Summary:Haemopoietic effects of ethylene glycol monomethyl ether (EGME) are described in three young women employed in a frame factory where the substance was applied under apparently safe hygienic conditions. In a ventilated room they used a mixture of acetone (70%) and EGME (30%) to glue together cellulose acetate frame components. During a periodic medical examination their white blood cell count was found to be abnormally low, with a relative lymphocytosis, macrocytosis with red blood cells, and haemoglobin at borderline normal values. These findings persisted over the exposure period but the haematological parameters returned to normal on stopping exposure. The subjects remained clinically healthy during the exposure period. This exposure to EGME occurred in an industry where such toxicity had not been previously reported and describes a situation in which the risk did not come from the exposure to vapour but most likely from an insufficient skin protection.
ISSN:0007-1072
1351-0711
1470-7926
DOI:10.1136/oem.49.2.131