Management of patients with statin intolerance

Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality, and statins have become a cornerstone in its treatment and prevention. Despite the well-documented benefits of statins, many patients stop taking them, with adverse muscle symptoms being a commonly cited reason. Al...

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Bibliographic Details
Published in:Baillière's best practice & research. Clinical endocrinology & metabolism 2023-05, Vol.37 (3), p.101714-101714, Article 101714
Main Authors: Martirossian, Alexandra Nicole, Goldberg, Anne Carol
Format: Article
Language:English
Subjects:
bempedoic acid
nocebo effect
statin intolerance
statin-associated muscle symptoms
statins
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Summary:Atherosclerotic cardiovascular disease is a leading cause of morbidity and mortality, and statins have become a cornerstone in its treatment and prevention. Despite the well-documented benefits of statins, many patients stop taking them, with adverse muscle symptoms being a commonly cited reason. Although some statin-associated adverse muscle effects are real, some can be attributed to the nocebo effect, which is the patient's perception of harm. The purpose of this article is to review the literature on statin safety, particularly that related to muscle, to analyze adverse effects, and to propose various treatment strategies for the statin intolerant patient.
ISSN:1521-690X
1878-1594
DOI:10.1016/j.beem.2022.101714