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Characterization and In Vivo Assay of Allantoin-Enriched Pectin Hydrogel for the Treatment of Skin Wounds

This work describes a liquid allantoin-enriched pectin hydrogel with hydrophilic behavior that is supported by the presence of functional groups related to healing efficacy. A topical study shows the effect of the hydrogel application on surgically induced skin wound healing in a rat model. Contact...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-04, Vol.24 (8), p.7377
Main Authors: Saucedo-Acuña, Rosa Alicia, Meza-Valle, Karen Zulema, Cuevas-González, Juan Carlos, Ordoñez-Casanova, Elsa Gabriela, Castellanos-García, Manuel Iván, Zaragoza-Contreras, Erasto Armando, Tamayo-Pérez, Genaro Federico
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Language:English
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Summary:This work describes a liquid allantoin-enriched pectin hydrogel with hydrophilic behavior that is supported by the presence of functional groups related to healing efficacy. A topical study shows the effect of the hydrogel application on surgically induced skin wound healing in a rat model. Contact angle measurements confirm hydrophilic behavior (11.37°), while Fourier-transform infrared spectroscopy indicates the presence of functional groups related to the healing effectiveness (carboxylic acid and amine groups). Allantoin is distributed on the surface and inside the amorphous pectin hydrogel surrounded by a heterogeneous distribution of pores. This promotes wound drying with better interaction between the hydrogel and cells involved in the wound healing process. An experimental study with female rats indicates that the hydrogel improves wound contraction, reducing around 71.43% of the total healing time and reaching total wound closure in 15 days.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms24087377