Protective Effects of a Polyphenolic Phytochemical Quercetin against Oxidative Dysfunctions in Rats

Background. Quercetin hastraditionally been used in various oxidative and urinary tract dysfunctions. Thecurrent project is consequently set to evaluate the defensive efficacy ofQuercetin against potassium bromate (KBrO3) induced testiculartissue oxidative dysfunctions through biochemical, hormonal,...

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Published in:Evidence-based complementary and alternative medicine 2023, Vol.2023 (1), p.7858718-7858718
Main Authors: Foudah, Ahmed I., Salkini, Mohammad A., Yusufoglu, Hasan Soliman, Alkreathy, Huda Mohammed, Khan, Rahmat Ali
Format: Article
Language:English
Subjects:
Antioxidants
Enzymatic activity
Enzymes
Free radicals
Histopathology
Hormones
Lipid peroxidation
Lipids
Mesothelioma
Nitrates
Peroxidation
Potassium
Potassium bromate
Proteins
Quercetin
Secretions
Testosterone
Thyroid gland
Urinary tract
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Summary:Background. Quercetin hastraditionally been used in various oxidative and urinary tract dysfunctions. Thecurrent project is consequently set to evaluate the defensive efficacy ofQuercetin against potassium bromate (KBrO3) induced testiculartissue oxidative dysfunctions through biochemical, hormonal, and genotoxicmarkers.Methods. To observe theprotective efficacy of Quercetin against urinogenital oxidative dysfunction inrats, thirty six albino male rats were divided into six groups. Protectiveefficacies of Quercetin were checked on reproductive hormonal levels,antioxidant enzyme activities, lipids peroxidation (LP), and DNA damages. Results. Potassium bromate exposure in experimentalanimals caused a reduction in the activities of antioxidant enzymes and disturbedhormonal secretions while enhancing the peroxidation of lipids andfragmentations of DNA. Cotreatment of Quercetin considerably (P
ISSN:1741-427X
1741-4288
DOI:10.1155/2023/7858718