Evaluation of oxidative stress-mediated cytotoxicity and genotoxicity of copper and flubendiamide: amelioration by antioxidants in vivo and in vitro

Abstract Present study was designed to evaluate toxic effects of copper (Cu) (@ 33 mg/kg b.wt.) and flubendimide (Flb) (@ 200 mg/kg b.wt.) alone and/or in combination on blood-biochemical indices, oxidative stress, and drug metabolizing enzymes (DMEs) in vivo in male Wistar rats following oral expos...

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Published in:Toxicology research (Cambridge) 2023-04, Vol.12 (2), p.232-252
Main Authors: Mandil, Rajesh, Prakash, Atul, Rahal, Anu, Koli, Swati, Kumar, Rahul, Garg, Satish K
Format: Article
Language:English
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Summary:Abstract Present study was designed to evaluate toxic effects of copper (Cu) (@ 33 mg/kg b.wt.) and flubendimide (Flb) (@ 200 mg/kg b.wt.) alone and/or in combination on blood-biochemical indices, oxidative stress, and drug metabolizing enzymes (DMEs) in vivo in male Wistar rats following oral exposure continuously for 90 days and their immunotoxic (cyto-genotoxic and apoptotic) potential in vitro on thymocytes. In in vivo study, ameliorative potential of α-tocopherol was assessed, whereas α-tocopherol, curcumin, resveratrol, and catechin were evaluated for protective effect in vitro. Significantly (P  resveratrol > catechin = α-tocopherol. Graphical Abstract Graphical Abstract
ISSN:2045-452X
2045-4538
2045-4538
DOI:10.1093/toxres/tfad011