Mesolimbocortical dementia: clinico-pathological studies on two cases

The clinicopathological findings are presented of two cases of mesolimbocortical dementia. Both cases were characterised by late onset slowly progressive personality changes and progressive intellectual deterioration without clinical Parkinsonism. Neuropathological findings revealed non-specific neu...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1990-06, Vol.53 (6), p.492-495
Main Authors: Verity, M A, Roitberg, B, Kepes, J J
Format: Article
Language:English
Subjects:
Aged
Atrophy
Biological and medical sciences
Caudate Nucleus - pathology
Cerebral Cortex - pathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Dementia - pathology
Depressive Disorder - pathology
Female
Glial Fibrillary Acidic Protein - analysis
Gliosis - pathology
Hippocampus - pathology
Humans
Limbic System - pathology
Male
Medical sciences
Mesencephalon - pathology
Nerve Degeneration - physiology
Neurology
Neurons - pathology
Parkinson Disease - pathology
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Summary:The clinicopathological findings are presented of two cases of mesolimbocortical dementia. Both cases were characterised by late onset slowly progressive personality changes and progressive intellectual deterioration without clinical Parkinsonism. Neuropathological findings revealed non-specific neuronal degeneration, Holzer and GFAP positive gliosis primarily affecting the limbic system, caudate, thalamus and substantia nigra. The pathological findings coincide with the distribution of the non-striatal dopaminergic pathways and suggest an intrinsic involvement of these pathways to account for the clinical and pathological manifestations.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.53.6.492