Antiviral Activity of Quercetin Hydrate against Zika Virus

Zika virus (ZIKV) has re-emerged in recent decades, leading to outbreaks of Zika fever in Africa, Asia, and Central and South America. Despite its drastic re-emergence and clinical impact, no vaccines or antiviral compounds are available to prevent or control ZIKV infection. This study evaluated the...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-04, Vol.24 (8), p.7504
Main Authors: Saivish, Marielena Vogel, Menezes, Gabriela de Lima, da Silva, Roosevelt Alves, Fontoura, Marina Alves, Shimizu, Jacqueline Farinha, da Silva, Gislaine Celestino Dutra, Teixeira, Igor da Silva, Mistrão, Natalia Franco Bueno, Hernandes, Victor Miranda, Rahal, Paula, Sacchetto, Lívia, Pacca, Carolina Colombelli, Marques, Rafael Elias, Nogueira, Maurício Lacerda
Format: Article
Language:English
Subjects:
Animals
Antiviral Agents - therapeutic use
Chlorocebus aethiops
Health aspects
Humans
Infection
Medical research
Medicine, Experimental
Molecular Docking Simulation
Prevention
Proteases
Quercetin - pharmacology
Quercetin - therapeutic use
Vaccines
Vero Cells
Virus Replication
Zika Virus
Zika Virus Infection
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Summary:Zika virus (ZIKV) has re-emerged in recent decades, leading to outbreaks of Zika fever in Africa, Asia, and Central and South America. Despite its drastic re-emergence and clinical impact, no vaccines or antiviral compounds are available to prevent or control ZIKV infection. This study evaluated the potential antiviral activity of quercetin hydrate against ZIKV infection and demonstrated that this substance inhibits virus particle production in A549 and Vero cells under different treatment conditions. In vitro antiviral activity was long-lasting (still observed 72 h post-infection), suggesting that quercetin hydrate affects multiple rounds of ZIKV replication. Molecular docking indicates that quercetin hydrate can efficiently interact with the specific allosteric binding site cavity of the NS2B-NS3 proteases and NS1-dimer. These results identify quercetin as a potential compound to combat ZIKV infection in vitro.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms24087504