Dopamine D1 receptors in Parkinson's disease and striatonigral degeneration: a positron emission tomography study

Striatal dopamine D1 receptors were investigated in 11 patients with Parkinson's disease (PD), five patients with striatonigral degeneration (SND) and six age-matched controls by positron emission tomography and carbon-11 labelled SCH23390. The SND patients showed mean 12%, 21%, and 31% decline...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1993-05, Vol.56 (5), p.467-472
Main Authors: Shinotoh, H, Inoue, O, Hirayama, K, Aotsuka, A, Asahina, M, Suhara, T, Yamazaki, T, Tateno, Y
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Brain - diagnostic imaging
Brain - physiology
Brain - physiopathology
Brain Diseases - diagnosis
Brain Diseases - physiopathology
Corpus Striatum - physiopathology
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Humans
Levodopa - therapeutic use
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Nerve Degeneration
Neurology
Parkinson Disease - diagnosis
Parkinson Disease - drug therapy
Parkinson Disease - physiopathology
Putamen - physiopathology
Radiography
Receptors, Dopamine D1
Tomography, Emission-Computed - methods
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Summary:Striatal dopamine D1 receptors were investigated in 11 patients with Parkinson's disease (PD), five patients with striatonigral degeneration (SND) and six age-matched controls by positron emission tomography and carbon-11 labelled SCH23390. The SND patients showed mean 12%, 21%, and 31% declines in the ratios of radioactivity in the caudate, anterior putamen, and posterior putamen compared with that in the occipital cortex. These ratios were not significantly altered in the PD patients. The results may explain the different therapeutic responses to levadopa between SND and PD patients, and this technique might prove useful for their differentiation.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.56.5.467