The use of botulinum toxin in the treatment of adductor spasmodic dysphonia

Botulinum toxin injections have been used to treat 31 patients with adductor spasmodic dysphonia. Injections of 3.00-3.75 units of botulinum toxin were performed bilaterally into the thyroarytenoid muscle. This treatment significantly decreased the standard deviation of the fundamental frequency of...

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Bibliographic Details
Published in:Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 1993-05, Vol.56 (5), p.526-530
Main Authors: Whurr, R, Lorch, M, Fontana, H, Brookes, G, Lees, A, Marsden, C D
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Botulinum Toxins - administration & dosage
Botulinum Toxins - therapeutic use
Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes
Female
Humans
Injections, Intramuscular
Male
Medical sciences
Middle Aged
Muscle Spasticity - drug therapy
Muscle Spasticity - physiopathology
Nervous system (semeiology, syndromes)
Neurology
Speech - drug effects
Vocal Cords - drug effects
Vocal Cords - physiopathology
Voice Disorders - diagnosis
Voice Disorders - drug therapy
Voice Disorders - physiopathology
Voice Quality
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Summary:Botulinum toxin injections have been used to treat 31 patients with adductor spasmodic dysphonia. Injections of 3.00-3.75 units of botulinum toxin were performed bilaterally into the thyroarytenoid muscle. This treatment significantly decreased the standard deviation of the fundamental frequency of the speech sample, indicating a reduction in the variability of pitch amongst patients. A total of 96% of patients' subjective diary reports showed an improvement with a median of 7 days to peak effect and a 5 week duration of peak effect.
ISSN:0022-3050
1468-330X
DOI:10.1136/jnnp.56.5.526