Adjunctive Dietary Therapy Is Associated With Improved Gastrointestinal Symptoms in Steroid-Refractory Gastrointestinal Graft-Versus-Host Disease: A Case Series

Acute gastrointestinal graft-versus-host disease (GI GVHD) is a complication after hematopoietic stem cell transplant with high morbidity and mortality. In particular, steroid-refractory GI GVHD can be difficult to treat. Recent investigations have revealed that patients after transplant can experie...

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Bibliographic Details
Published in:JPGN reports 2022-05, Vol.3 (2), p.e203-e203
Main Authors: Kaenkumchorn, Tanyaporn, Suskind, David L, Lee, Dale, Singh, Namita, Ford, Madeline, Skeen, Kristina, Macris, Paula C, Yeung, Cecilia, Summers, Corinne, Carpenter, Paul A, Zheng, Hengqi B
Format: Article
Language:English
Subjects:
Brief Report
Gastroenterology
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Summary:Acute gastrointestinal graft-versus-host disease (GI GVHD) is a complication after hematopoietic stem cell transplant with high morbidity and mortality. In particular, steroid-refractory GI GVHD can be difficult to treat. Recent investigations have revealed that patients after transplant can experience intestinal dysbiosis contributing to the progression of GVHD. Modulation of the gut microbiome through dietary intake could potentially improve the intestinal dysbiosis in GI GVHD. In this case series, we present 3 patients where dietary therapy was used in conjunction with immunosuppression to achieve clinical remission of GI GVHD.
ISSN:2691-171X
2691-171X
DOI:10.1097/PG9.0000000000000203