Seroprevalence of Crimean-Congo Hemorrhagic Fever Virus and Rift Valley Fever Virus in human population in Senegal from October to November 2020

• Published in: IJID regions 2023-06, Vol.7, p.216-221
• Main Authors: Sankhe, Safietou, Talla, Cheikh, Thiam, Mareme Seye, Faye, Martin, Barry, Mamadou Aliou, Diarra, Maryam, Dia, Moussa, Ndiaye, Oumar, Sembene, Pape Mbacke, Diop, Boly, Fall, Gamou, Faye, Oumar, Faye, Ousmane, Diagne, Moussa Moise, Loucoubar, Cheikh
• Format: Article
• Language: English
• Subjects: Africa; Crimean-Congo Hemorrhagic Fever; Original Report; Rift Valley Fever; Senegal; seroprevalence
• ISSN: 2772-7076; 2772-7076
• DOI: 10.1016/j.ijregi.2023.03.016

•RVF/CCHF outbreaks and sporadic human cases are increasingly reported in Senegal.•Only a few investigations have been conducted in human populations at a national scale.•To our knowledge, this is the first nationwide seroprevalence study in a human population.•Acute infections in both high and low exposed areas suggesting sporadic introductions.•Additional holistic studies are needed to determine risk factors for these zoonoses. Rift Valley Fever and Crimean-Congo Hemorrhagic Fever are two infections classified among the emerging diseases to be monitored with highest priority. Studies undertaken in human and animals have shown endemicity of these two arboviruses in several African countries. However, most of the investigations were carried out on domestic cattle and the studies conducted on human populations are either outdated or limited to a small number of well-known endemic areas. It is then critical to better evaluate the burden of these viruses in Senegal at a national scale. This work relies on a previous seroprevalence survey undertaken in all regions of Senegal at the end of 2020. The existing biobank was used to determine the immunoglobulin G [IgG] Rift Valley Fever and Crimean-Congo Hemorrhagic Fever seroprevalences by indirect enzyme-linked immunosorbent assay. The crude seroprevalences of Rift Valley Fever and Crimean-Congo Hemorrhagic Fever were 3.94% and 0.7% respectively, with the northern and central part of the countries as the main exposed areas. However, acute infections reported in both high and low exposed regions suggest sporadic introductions. This study gives updated information and could be of interest to support the stakeholders in the management of these zoonoses.