A Case of Acute Encephalopathy After the Initiation of FOLFOX Chemotherapy in a Patient With Colon Cancer

Acute encephalopathy is a change in the level of consciousness where the underlying etiology can be difficult to diagnose, and thus, difficult to treat, especially in the context of multi-organ diseases. We report a case of acute encephalopathy in a patient with end-stage renal disease (ESRD) on hem...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-04, Vol.15 (4), p.e37237
Main Authors: Kim, Jin S, Lio, Ka U, Henderson, Hannah, Pourshahid, Seyedmohammad
Format: Article
Language:English
Subjects:
Ammonia
Blood pressure
Cancer therapies
Case reports
Cerebrospinal fluid
Chemotherapy
Colorectal cancer
Consciousness
Creatinine
Cytomegalovirus
Diabetes
Diagnostic tests
Disease
Emergency medical care
Etiology
Glucose
Hemodialysis
Hospitals
Hypotension
Hypothyroidism
Internal Medicine
Intubation
Ischemia
Medical diagnosis
Metabolism
Oncology
Potassium
Uremia
Ventilators
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Summary:Acute encephalopathy is a change in the level of consciousness where the underlying etiology can be difficult to diagnose, and thus, difficult to treat, especially in the context of multi-organ diseases. We report a case of acute encephalopathy in a patient with end-stage renal disease (ESRD) on hemodialysis, chronic hypotension, and a recent diagnosis of colon cancer who presented shortly after initiation of FOLFOX, a chemotherapy regimen for treatment of colorectal cancer comprised of folinic acid (leucovorin), fluorouracil (5-FU), and oxaliplatin (eloxatin). We present a systematic approach to elucidate ambiguous causes of toxic-metabolic encephalopathy.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.37237