Does large volume of distribution of lidocaine masks its systemic uptake from bladder?

To assess whether therapeutic and toxic effects of intravesical lidocaine are determined by coincident serum levels. Published clinical trials and case studies on instilled lidocaine 1-2% that reported serum lidocaine levels were analyzed using model independent pharmacokinetic equations to compute...

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Bibliographic Details
Published in:American journal of clinical and experimental urology 2023-01, Vol.11 (2), p.121-135
Main Authors: Tyagi, Pradeep, Ganguly, Anirban, Chermansky, Christopher, Tarin, Tatum V, Yoshimura, Naoki, Maranchie, Jodi
Format: Article
Language:English
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Summary:To assess whether therapeutic and toxic effects of intravesical lidocaine are determined by coincident serum levels. Published clinical trials and case studies on instilled lidocaine 1-2% that reported serum lidocaine levels were analyzed using model independent pharmacokinetic equations to compute the absorbed dose fraction (F) for linear regression with the respective dwell times. Rapid absorption of intravesical lidocaine is evinced by the serum levels of 0.16±0.3 mg/L at 5 min in bladder cancer patients coinciding with the rapid onset of pain relief (
ISSN:2330-1910
2330-1910