Consanguinity and increased risk of congenital ptosis: A case-Control study from Southern Iran

Purpose: To assess consanguinity as a probable risk factor for congenital ptosis. Methods: In this case-control study, 97 patients with congenital ptosis and 97 participants as the control group were included. The age, sex, and residence area of the control group were matched with the cases. The inb...

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Bibliographic Details
Published in:Iranian journal of ophthalmology 2022-10, Vol.34 (4), p.465-468
Main Authors: Khalili, Mohammad, Owji, Naser, Zarei, Elahe, Nazari, Mohammadreza
Format: Article
Language:English
Subjects:
Congenital diseases
Eye diseases
Eyes & eyesight
Genetics
Health risks
Original
Paralysis
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Summary:Purpose: To assess consanguinity as a probable risk factor for congenital ptosis. Methods: In this case-control study, 97 patients with congenital ptosis and 97 participants as the control group were included. The age, sex, and residence area of the control group were matched with the cases. The inbreeding coefficient (F) was calculated for each participant, and the mean of the inbreeding coefficient (α) was calculated for each group. Results: The prevalence of consanguineous marriage in parents of cases with congenital ptosis and those of the control group was 54.6% and 30.9%, respectively (P < 0.002). The mean of the inbreeding coefficient (α) in patients with ptosis was 0.026, whereas it was 0.016 in the control group (T = 2.51, degree of freedom = 192, P = 0.0129). Conclusions: The rate of consanguineous marriage was significantly higher among the parents of patients with congenital ptosis. It implies a probable recessive pattern in the etiology of congenital ptosis.
ISSN:2452-2325
2452-2325
DOI:10.4103/joco.joco_136_22