More extensive white matter disruptions present in untreated obstructive sleep apnea than we thought: A large sample diffusion imaging study

Obstructive sleep apnea (OSA) may lead to white mater (WM) disruptions and cognitive deficits. However, no studies have investigated the full extent of the brain WM, and its associations with cognitive deficits in OSA remain unclear. We thus applied diffusion tensor imaging (DTI) tractography with m...

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Bibliographic Details
Published in:Human brain mapping 2023-06, Vol.44 (8), p.3045-3056
Main Authors: Koo, Dae Lim, Cabeen, Ryan P., Yook, Soon Hyun, Cen, Steven Yong, Joo, Eun Yeon, Kim, Hosung
Format: Article
Language:English
Subjects:
Abnormalities
Anisotropy
Apnea
Body mass
Body mass index
Body size
Brain - diagnostic imaging
Brain stem
brainstem
Cerebellum
Cerebral cortex
Cognitive ability
Corpus callosum
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging - methods
Disease
Executive function
Fibers
Humans
Intelligence tests
Lemniscus (medial)
Magnetic resonance imaging
Medical imaging
Memory
Neuroimaging
Neuropsychology
obstructive sleep apnea
Quantitative analysis
Rostrum
Sleep apnea
Sleep Apnea, Obstructive - diagnostic imaging
Sleep disorders
Substantia alba
Tensors
Thalamus
tractography
white matter
White Matter - diagnostic imaging
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Summary:Obstructive sleep apnea (OSA) may lead to white mater (WM) disruptions and cognitive deficits. However, no studies have investigated the full extent of the brain WM, and its associations with cognitive deficits in OSA remain unclear. We thus applied diffusion tensor imaging (DTI) tractography with multi‐fiber models and used atlas‐based bundle‐specific approach to investigate the WM abnormalities for various tracts of the cerebral cortex, thalamus, brainstem, and cerebellum in patients with untreated OSA. We enrolled 100 OSA patients and 63 healthy controls. Fractional anisotropy (FA) and mean diffusivity (MD) values mapped on 33 regions of interest including WM tracts of cortex, thalamus, brainstem, and cerebellum were obtained from tractography‐based reconstructions. We compared FA/MD values between groups and correlated FA/MD with clinical data in the OSA group after controlling for age and body mass index. OSA patients showed significantly lower FA values in multiple WM fibers including corpus callosum, inferior fronto‐occipital fasciculus, middle/superior longitudinal fasciculi, thalamic radiations, and uncinate (FDR 
ISSN:1065-9471
1097-0193
DOI:10.1002/hbm.26261