An Automated, Home-Cage, Video Monitoring-based Mouse Frailty Index Detects Age-associated Morbidity in C57BL/6 and Diversity Outbred Mice

Abstract Frailty indexes (FIs) provide quantitative measurements of nonspecific health decline and are particularly useful as longitudinal monitors of morbidity in aging studies. For mouse studies, frailty assessments can be taken noninvasively, but they require handling and direct observation that...

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Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2023-05, Vol.78 (5), p.762-770
Main Authors: Ruby, J Graham, Di Francesco, Andrea, Ylagan, Paulo, Luo, Angela, Keyser, Robert, Williams, Owen, Spock, Sarah, Li, Wenzhou, Vongtharangsy, Nalien, Chatterjee, Sandip, Sloan, Cricket A, Ledogar, Charles, Kuiper, Veronica, Kite, Janessa, Cosino, Marcelo, Cha, Paulyn, Karlsson, Eleanor M
Format: Article
Language:English
Subjects:
Aged
Aging
Animals
Collaborative Cross Mice
Frail Elderly
Frailty
Frailty - diagnosis
Genetics
Geriatric Assessment
Gerontology
Humans
Indexes
Mice
Mice, Inbred C57BL
Morbidity
THE JOURNAL OF GERONTOLOGY: Biological Sciences
Workplace diversity
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Summary:Abstract Frailty indexes (FIs) provide quantitative measurements of nonspecific health decline and are particularly useful as longitudinal monitors of morbidity in aging studies. For mouse studies, frailty assessments can be taken noninvasively, but they require handling and direct observation that is labor-intensive to the scientist and stress inducing to the animal. Here, we implement, evaluate, and provide a refined digital FI composed entirely of computational analyses of home-cage video and compare it to manually obtained frailty scores in both C57BL/6 and genetically heterogeneous Diversity Outbred mice. We show that the frailty scores assigned by our digital index correlate with both manually obtained frailty scores and chronological age. Thus, we provide an automated tool for frailty assessment that can be collected reproducibly, at scale, without substantial labor cost.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glad035