Influencing factors of early dramatic recovery of neurological function after intravenous thrombolysis in patients with branch atheromatous disease

Intravenous thrombolysis can significantly improve the neurological function of patients with acute ischemic stroke. However, the expected early dramatic recovery (EDR) of neurological function after thrombolysis is not achieved in some patients with branch atheromatous disease (BAD). Here we evalua...

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Published in:Medicine (Baltimore) 2023-05, Vol.102 (19), p.e33658-e33658
Main Authors: Meng, Yuanyuan, Zhao, Yanjun, Wang, Ruixia, Wen, Jiangshan, Tang, Tianping
Format: Article
Language:English
Subjects:
Brain Ischemia - drug therapy
Clinical Trial/Experimental Study
Fibrinolytic Agents - therapeutic use
Humans
Ischemic Stroke - drug therapy
Retrospective Studies
Stroke - complications
Stroke - etiology
Thrombolytic Therapy
Tissue Plasminogen Activator - therapeutic use
Treatment Outcome
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Summary:Intravenous thrombolysis can significantly improve the neurological function of patients with acute ischemic stroke. However, the expected early dramatic recovery (EDR) of neurological function after thrombolysis is not achieved in some patients with branch atheromatous disease (BAD). Here we evaluated the factors associated with EDR after thrombolysis in BAD patients. We conducted a retrospective study on 580 consecutive BAD patients. All patients met the diagnostic criteria of BAD and received intravenous recombinant tissue-type plasminogen activator (rt-PA). EDR was defined when the improvement of National Institutes of Health Stroke Scale (NIHSS) score was >8 points within 2 or 24 hours after rt-PA, or the total NIHSS score was 0 or 1. The factors associated with EDR were analyzed with multivariate logistic regression analysis. Among 580 patients, the incidence of EDR was 35.2% (204 cases). Compared with patients without EDR, patients with EDR had lower incidence of diabetes (15.7% vs 29.3%, P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000033658