Plasma Antithrombin III Levels Can Be a Prognostic Factor in Liver Cirrhosis Patients with Portal Vein Thrombosis

Liver function influences the plasma antithrombin (AT)-III levels. AT-III is beneficial for patients with portal vein thrombosis (PVT) and low plasma AT-III levels. However, whether these levels affect prognosis in patients with cirrhosis-associated PVT remains unknown. This retrospective study invo...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-04, Vol.24 (9), p.7732
Main Authors: Suda, Tsuyoshi, Takatori, Hajime, Hayashi, Takehiro, Kaji, Kiichiro, Nio, Kouki, Terashima, Takeshi, Shimakami, Tetsuro, Arai, Kuniaki, Yamashita, Tatsuya, Mizukoshi, Eishiro, Honda, Masao, Okumura, Kenichiro, Kozaka, Kazuto, Yamashita, Taro
Format: Article
Language:English
Subjects:
Albumins
Analysis
Anticoagulants
Antithrombin
Antithrombin III
Bilirubin
Blood clot
Carcinoma, Hepatocellular - pathology
Care and treatment
Cirrhosis
Danaparoid
Death
Health aspects
Hepatocellular carcinoma
Humans
Japan
Liver
Liver cancer
Liver cirrhosis
Liver Cirrhosis - pathology
Liver diseases
Liver Failure - pathology
Liver Neoplasms - pathology
Medical prognosis
Medical research
Medicine, Experimental
Mortality
Plasma
Portal Vein
Prognosis
Retrospective Studies
Survival
Survival analysis
Taiwan
Thrombosis
Venous Thrombosis
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Summary:Liver function influences the plasma antithrombin (AT)-III levels. AT-III is beneficial for patients with portal vein thrombosis (PVT) and low plasma AT-III levels. However, whether these levels affect prognosis in patients with cirrhosis-associated PVT remains unknown. This retrospective study involved 75 patients with cirrhosis and PVT treated with danaparoid sodium with or without AT-III. The plasma AT-III level was significantly lower in patients with liver failure-related death than in those with hepatocellular carcinoma (HCC)-related death ( = 0.005), although the Child-Pugh and albumin-bilirubin (ALBI) scores were not significantly different between these two groups. Receiver operating characteristic curve analysis of the plasma AT-III levels showed cutoff values of 54.0% at 5-year survival. Low plasma AT-III levels (
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24097732