APP in the Neuromuscular Junction for the Development of Sarcopenia and Alzheimer's Disease

Sarcopenia, an illness condition usually characterized by a loss of skeletal muscle mass and muscle strength or function, is often associated with neurodegenerative diseases, such as Alzheimer's disease (AD), a common type of dementia, leading to memory loss and other cognitive impairment. Howe...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-04, Vol.24 (9), p.7809
Main Authors: Wu, Min-Yi, Zou, Wen-Jun, Lee, Daehoon, Mei, Lin, Xiong, Wen-Cheng
Format: Article
Language:English
Subjects:
Aging
Alzheimer Disease - metabolism
Alzheimer's disease
Amyloid beta-Peptides - metabolism
Amyloid beta-Protein Precursor - genetics
Amyloid beta-Protein Precursor - metabolism
Amyloid precursor protein
Atrophy
Central nervous system
Cognitive ability
Cohort analysis
Dementia
Dementia disorders
Health risk assessment
Humans
Malnutrition
Muscle strength
Musculoskeletal system
Neurodegeneration
Neuromuscular diseases
Neuromuscular Junction - metabolism
Neuromuscular junctions
Neurons
Older people
Peptides
Proteins
Review
Sarcopenia
Sarcopenia - metabolism
Skeletal muscle
Synapses
Synapses - metabolism
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Summary:Sarcopenia, an illness condition usually characterized by a loss of skeletal muscle mass and muscle strength or function, is often associated with neurodegenerative diseases, such as Alzheimer's disease (AD), a common type of dementia, leading to memory loss and other cognitive impairment. However, the underlying mechanisms for their associations and relationships are less well understood. The , a Mendelian gene for early-onset AD, encodes amyloid precursor protein (APP), a transmembrane protein enriched at both the neuromuscular junction (NMJ) and synapses in the central nervous system (CNS). Here, in this review, we highlight APP and its family members' physiological functions and Swedish mutant APP (APP )'s pathological roles in muscles and NMJ. Understanding APP's pathophysiological functions in muscles and NMJ is likely to uncover insights not only into neuromuscular diseases but also AD. We summarize key findings from the burgeoning literature, which may open new avenues to investigate the link between muscle cells and brain cells in the development and progression of AD and sarcopenia.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24097809