Role of Sex Hormones in Prevalent Kidney Diseases

Chronic kidney disease (CKD) is a constantly growing global health burden, with more than 840 million people affected worldwide. CKD presents sex disparities in the pathophysiology of the disease, as well as in the epidemiology, clinical manifestations, and disease progression. Overall, while CKD is...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-05, Vol.24 (9), p.8244
Main Authors: Conte, Carolina, Antonelli, Giulia, Melica, Maria Elena, Tarocchi, Mirko, Romagnani, Paola, Peired, Anna Julie
Format: Article
Language:English
Subjects:
Androgens
Cardiovascular disease
Chronic kidney failure
Development and progression
Diabetes mellitus
Diabetic Nephropathies - epidemiology
Disease Progression
End-stage renal disease
Epidemiology
Estrogens
Female
Gonadal Steroid Hormones
Hormone replacement therapy
Hormones, Sex
Humans
IgA nephropathy
Immunoglobulin A
Industrialized nations
Kidney
Kidney diseases
Kidney Failure, Chronic
Kidney transplants
Lupus
Lupus nephritis
Male
Males
Menopause
Nephritis
Nephrology
Oophorectomy
Ovaries
Physiology
Polycystic kidney
Public health
Renal Insufficiency, Chronic - epidemiology
Review
Sex hormones
Testosterone
Transgender persons
Womens health
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Summary:Chronic kidney disease (CKD) is a constantly growing global health burden, with more than 840 million people affected worldwide. CKD presents sex disparities in the pathophysiology of the disease, as well as in the epidemiology, clinical manifestations, and disease progression. Overall, while CKD is more frequent in females, males have a higher risk to progress to end-stage kidney disease. In recent years, numerous studies have highlighted the role of sex hormones in the health and diseases of several organs, including the kidney. In this review, we present a clinical overview of the sex-differences in CKD and a selection of prominent kidney diseases causing CKD: lupus nephritis, diabetic kidney disease, IgA nephropathy, and autosomal dominant polycystic kidney disease. We report clinical and experimental findings on the role of sex hormones in the development of the disease and its progression to end-stage kidney disease.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24098244