Cell Therapy as Target Therapy against Colon Cancer Stem Cells

Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with properties, such as self-renewal, differentiation, and tumorigenicity. CSCs have been proposed as a plausible therapeutic target as they are responsible for tumor recurrence, metastasis, and conventional therapy resistanc...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-05, Vol.24 (9), p.8163
Main Authors: Garza Treviño, Elsa N, Quiroz Reyes, Adriana G, Rojas Murillo, Juan Antonio, de la Garza Kalife, David A, Delgado Gonzalez, Paulina, Islas, Jose F, Estrada Rodriguez, Ana Esther, Gonzalez Villarreal, Carlos A
Format: Article
Language:English
Subjects:
Antibodies
Apoptosis
Cancer
Cancer therapies
Care and treatment
Cell adhesion & migration
Cell cycle
Cell growth
Cell proliferation
Cell self-renewal
Cell therapy
Chemotherapy
Colon cancer
Colonic Neoplasms - pathology
Colorectal cancer
Colorectal carcinoma
Cytotoxicity
Development and progression
Drug resistance
Genes
Glycoproteins
Health aspects
Humans
Immune system
Immunotherapy
Kinases
Ligands
Lymphocytes
Lymphocytes T
Macrophages
Medical prognosis
Metastases
Metastasis
Natural killer cells
Neoplasm Recurrence, Local - pathology
Neoplastic Stem Cells - metabolism
Proteins
Radiation therapy
Review
Signal transduction
Stem cells
Surgery
T cells
Therapeutic targets
Transplantation
Tumor cells
Tumorigenicity
Tumors
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Description
Summary:Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with properties, such as self-renewal, differentiation, and tumorigenicity. CSCs have been proposed as a plausible therapeutic target as they are responsible for tumor recurrence, metastasis, and conventional therapy resistance. Selectively targeting CSCs is a promising strategy to eliminate the propagation of tumor cells and impair overall tumor development. Recent research shows that several immune cells play a crucial role in regulating tumor cell proliferation by regulating different CSC maintenance or proliferation pathways. There have been great advances in cellular immunotherapy using T cells, natural killer (NK) cells, macrophages, or stem cells for the selective targeting of tumor cells or CSCs in colorectal cancer (CRC). This review summarizes the CRC molecular profiles that may benefit from said therapy and the main vehicles used in cell therapy against CSCs. We also discuss the challenges, limitations, and advantages of combining conventional and/or current targeted treatments in the late stages of CRC.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24098163