New Insight into the Molecular Pathomechanism and Immunomodulatory Treatments of Hidradenitis Suppurativa

Hidradenitis suppurativa (HS) is an immune-mediated inflammatory disorder characterized by deep-seated nodules, abscesses, sinus tracts and scars localized in the intertriginous areas. It is accompanied by pain, malodourous secretion and a dramatically decreased quality of life. Although the pathoge...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-05, Vol.24 (9), p.8428
Main Authors: Molinelli, Elisa, Gioacchini, Helena, Sapigni, Claudia, Diotallevi, Federico, Brisigotti, Valerio, Rizzetto, Giulio, Offidani, Annamaria, Simonetti, Oriana
Format: Article
Language:English
Subjects:
Abscess
Abscesses
Adalimumab
Adalimumab - therapeutic use
Antibiotics
Care and treatment
Cysts
Cytokines
Cytokines - therapeutic use
Dalbavancin
Dendritic cells
Development and progression
Disease
Hair
Health aspects
Hidradenitis Suppurativa - complications
Humans
Hyperplasia
Immune system
Immunomodulation
Inflammation
Inflammatory diseases
Monoclonal antibodies
Neutrophils
Nodules
Obesity
Pathogenesis
Plastic surgery
Psoriasis
Quality of Life
Review
Sinuses
Skin
Skin & tissue grafts
Tetracycline
Tetracyclines
Therapeutic targets
Tumor necrosis factor
Tumor necrosis factor-TNF
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Description
Summary:Hidradenitis suppurativa (HS) is an immune-mediated inflammatory disorder characterized by deep-seated nodules, abscesses, sinus tracts and scars localized in the intertriginous areas. It is accompanied by pain, malodourous secretion and a dramatically decreased quality of life. Although the pathogenesis has not been entirely elucidated, the primary event is follicular hyperkeratosis of the pilosebaceous apocrine unit. Since the registration of the tumor necrosis factor-alpha inhibitor Adalimumab in 2015, several cytokines have been implicated in the pathomechanism of HS and the research of novel therapeutic targets has been intensified. We provide an update on the inflammatory cytokines with a central role in HS pathogenesis and the most promising target molecules of future HS management.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24098428