Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis

This paper presents a systematic review and meta-analysis of 26 randomized controlled trials (RCTs) involving 1721 patients to assess the effects of hydrolyzed collagen (HC) supplementation on skin hydration and elasticity. The results showed that HC supplementation significantly improved skin hydra...

Full description

Saved in:
Bibliographic Details
Published in:Nutrients 2023-04, Vol.15 (9), p.2080
Main Authors: Pu, Szu-Yu, Huang, Ya-Li, Pu, Chi-Ming, Kang, Yi-No, Hoang, Khanh Dinh, Chen, Kee-Hsin, Chen, Chiehfeng
Format: Article
Language:English
Subjects:
Aging
Bias
Biopsy
Blood
Care and treatment
Clinical trials
Collagen
Collagen - pharmacology
Comparative analysis
Elasticity
Hemoglobin
Humans
Hyaluronic acid
Hydration
Medical research
Medicine, Experimental
Meta-analysis
Peptides
Questionnaires
Sensitivity analysis
Skin
Skin tests
Subgroups
Systematic Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This paper presents a systematic review and meta-analysis of 26 randomized controlled trials (RCTs) involving 1721 patients to assess the effects of hydrolyzed collagen (HC) supplementation on skin hydration and elasticity. The results showed that HC supplementation significantly improved skin hydration (test for overall effect: Z = 4.94, < 0.00001) and elasticity (test for overall effect: Z = 4.49, < 0.00001) compared to the placebo group. Subgroup analyses demonstrated that the effects of HC supplementation on skin hydration varied based on the source of collagen and the duration of supplementation. However, there were no significant differences in the effects of different sources ( = 0.21) of collagen or corresponding measurements ( = 0.06) on skin elasticity. The study also identified several biases in the included RCTs. Overall, the findings suggest that HC supplementation can have positive effects on skin health, but further large-scale randomized control trials are necessary to confirm these findings.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu15092080