Association of oral lichen planus with hepatic disorders and hepatocellular carcinoma: systematic review and meta-analysis

• Published in: Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2023-05, Vol.28 (3), p.e229-e237
• Main Authors: González-Moles, M-Á, de Porras-Carrique, T, Ramos-García, P
• Format: Article
• Language: English
• Subjects: Carcinoma, Hepatocellular - complications; Fatty Liver; Humans; Lichen Planus, Oral - complications; Lichen Planus, Oral - pathology; Liver Neoplasms - complications; Review; Risk Factors
• ISSN: 1698-6946; 1698-4447; 1698-6946
• DOI: 10.4317/medoral.25661

Oral lichen planus (OLP) is a prevalent autoimmune chronic inflammatory disease of unknown etiology. The importance of the association between hepatic disease and OLP lies in the fact that many of these disorders (HC, HB, cirrhosis, hepatic steatosis) behave as risk factors for hepatocellular carcinoma. We searched PubMed, Embase, Web of Science, and Scopus for studies published before January 2022. We evaluated the quality of studies (Joanna Briggs Institute tool). We performed meta-analyses, investigated the heterogeneity between studies, and we also carried out subgroups, meta-regression, and small-study effects analyses. 146 studies (21,187 patients) were included in this study. Our study aims to evaluate current evidence on the prevalence and magnitude of association between hepatic diseases (especially those with risk of malignancy), hepatocellular carcinoma and OLP. Our results suggest that patients with OLP present a significant tendency to the development of hepatitis B (OR=1.62, 95%CI=1.01-2.40, p=0.02), hepatitis C (OR=4.09, 95%CI=2.77-6.03, p