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Clinical Significance of the Prealbumin Level in Gastric Cancer Patients Who Receive Curative Treatment
Background We investigated the clinical influence of the prealbumin level on the gastric cancer survival and recurrence after curative treatment. Methods This study included 447 patients who underwent curative treatment for gastric cancer between 2013 and 2017. The risk factors for the overall survi...
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| Published in: | Journal of gastrointestinal cancer 2023-03, Vol.54 (1), p.27-34 |
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| Main Authors: | , , , , , , , , , , , , , , , |
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| container_end_page | 34 |
| container_issue | 1 |
| container_start_page | 27 |
| container_title | Journal of gastrointestinal cancer |
| container_volume | 54 |
| creator | Aoyama, Toru Nakazono, Masato Segami, Kenki Nagasawa, Shinsuke Kano, Kazuki Hara, Kentaro Maezawa, Yukio Hashimoto, Itaru Suematsu, Hideaki Watanabe, Hayato Komori, Keisuke Tamagawa, Hiroshi Yukawa, Norio Rino, Yasushi Ogata, Takashi Oshima, Takashi |
| description | Background
We investigated the clinical influence of the prealbumin level on the gastric cancer survival and recurrence after curative treatment.
Methods
This study included 447 patients who underwent curative treatment for gastric cancer between 2013 and 2017. The risk factors for the overall survival (OS) and recurrence-free survival (RFS) were identified.
Results
A prealbumin level of 20 mg/dl was regarded as the optimal point of classification, considering the 3- and 5-year survival rates. The OS rates at 3 and 5 years after surgery were 80.7% and 65.0% in the low-prealbumin group, respectively, and 93.1% and 87.9% in the high-prealbumin group, respectively, a statistically significant difference (
p
|
| doi_str_mv | 10.1007/s12029-021-00777-w |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10182926</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2611651455</sourcerecordid><originalsourceid>FETCH-LOGICAL-c513t-ef8240d039a33ee50ce482fc486838c650be5bb3fcb3c8497cff1102cfad0ebc3</originalsourceid><addsrcrecordid>eNp9UctO5DAQtFaLlucPcEA-7iXgthMnOa1QxALSSCAe4mg5nvaMUeKAnQzi79cwMFounFzuqq5udRFyCOwYGCtPInDG64xxyNK3LLOXH2QH6hwyKYX8ucG82ia7MT4yJvMC4BfZFnnNQZawQxZN57wzuqO3buGdTdAbpIOl4xLpdUDdtVPvPJ3hCjuawLmOY3CGNm_CQK_16NCPkT4sB3qDBt0KaTOFVE7gLhmMfeL3yZbVXcSDj3eP3P89u2sustnV-WVzOstMAWLM0FY8Z3Mmai0EYsEM5hW3Jq9kJSojC9Zi0bbCmlaYKq9LYy0A48bqOcPWiD3yZ-37NLU9zk0aHXSnnoLrdXhVg3bqK-PdUi2GlQIGFa-5TA6_PxzC8DxhHFXvosGu0x6HKSouAWQBeVEkKV9LTRhiDGg3c4Cpt4jUOiKVIlLvEamX1HT0_4abls9MkkCsBTFRfoFBPQ5T8Olq39n-A-b3n3c</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2611651455</pqid></control><display><type>article</type><title>Clinical Significance of the Prealbumin Level in Gastric Cancer Patients Who Receive Curative Treatment</title><source>Springer Link</source><creator>Aoyama, Toru ; Nakazono, Masato ; Segami, Kenki ; Nagasawa, Shinsuke ; Kano, Kazuki ; Hara, Kentaro ; Maezawa, Yukio ; Hashimoto, Itaru ; Suematsu, Hideaki ; Watanabe, Hayato ; Komori, Keisuke ; Tamagawa, Hiroshi ; Yukawa, Norio ; Rino, Yasushi ; Ogata, Takashi ; Oshima, Takashi</creator><creatorcontrib>Aoyama, Toru ; Nakazono, Masato ; Segami, Kenki ; Nagasawa, Shinsuke ; Kano, Kazuki ; Hara, Kentaro ; Maezawa, Yukio ; Hashimoto, Itaru ; Suematsu, Hideaki ; Watanabe, Hayato ; Komori, Keisuke ; Tamagawa, Hiroshi ; Yukawa, Norio ; Rino, Yasushi ; Ogata, Takashi ; Oshima, Takashi</creatorcontrib><description>Background
We investigated the clinical influence of the prealbumin level on the gastric cancer survival and recurrence after curative treatment.
Methods
This study included 447 patients who underwent curative treatment for gastric cancer between 2013 and 2017. The risk factors for the overall survival (OS) and recurrence-free survival (RFS) were identified.
Results
A prealbumin level of 20 mg/dl was regarded as the optimal point of classification, considering the 3- and 5-year survival rates. The OS rates at 3 and 5 years after surgery were 80.7% and 65.0% in the low-prealbumin group, respectively, and 93.1% and 87.9% in the high-prealbumin group, respectively, a statistically significant difference (
p
< 0.001). The RFS rates at 3 and 5 years after surgery were 71.7% and 68.0% in the low-prealbumin group, respectively, and 90.1% and 84.7% in the high-prealbumin group, respectively, a statistically significant difference (
p
= 0.031). A multivariate analysis demonstrated that the prealbumin level was a significant independent risk factor for the OS and RFS. In addition, the rate of introduction of adjuvant chemotherapy was significantly lower and the frequency of peritoneal recurrence and lymph node recurrence significantly higher in the low-prealbumin group than in the high-prealbumin group.
Conclusion
Prealbumin is a risk factor for the survival in patients who undergo curative treatment for gastric cancer. It is necessary to develop an effective plan of perioperative care and surgical strategy according to the prealbumin level.</description><identifier>ISSN: 1941-6628</identifier><identifier>EISSN: 1941-6636</identifier><identifier>DOI: 10.1007/s12029-021-00777-w</identifier><identifier>PMID: 34921671</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Cancer Research ; Clinical Relevance ; Gastroenterology ; Humans ; Internal Medicine ; Lymph Nodes ; Medicine ; Medicine & Public Health ; Neoplasm Recurrence, Local - epidemiology ; Oncology ; Original Research ; Prealbumin ; Prognosis ; Radiotherapy ; Retrospective Studies ; Risk Factors ; Stomach Neoplasms - surgery</subject><ispartof>Journal of gastrointestinal cancer, 2023-03, Vol.54 (1), p.27-34</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-ef8240d039a33ee50ce482fc486838c650be5bb3fcb3c8497cff1102cfad0ebc3</citedby><cites>FETCH-LOGICAL-c513t-ef8240d039a33ee50ce482fc486838c650be5bb3fcb3c8497cff1102cfad0ebc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34921671$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aoyama, Toru</creatorcontrib><creatorcontrib>Nakazono, Masato</creatorcontrib><creatorcontrib>Segami, Kenki</creatorcontrib><creatorcontrib>Nagasawa, Shinsuke</creatorcontrib><creatorcontrib>Kano, Kazuki</creatorcontrib><creatorcontrib>Hara, Kentaro</creatorcontrib><creatorcontrib>Maezawa, Yukio</creatorcontrib><creatorcontrib>Hashimoto, Itaru</creatorcontrib><creatorcontrib>Suematsu, Hideaki</creatorcontrib><creatorcontrib>Watanabe, Hayato</creatorcontrib><creatorcontrib>Komori, Keisuke</creatorcontrib><creatorcontrib>Tamagawa, Hiroshi</creatorcontrib><creatorcontrib>Yukawa, Norio</creatorcontrib><creatorcontrib>Rino, Yasushi</creatorcontrib><creatorcontrib>Ogata, Takashi</creatorcontrib><creatorcontrib>Oshima, Takashi</creatorcontrib><title>Clinical Significance of the Prealbumin Level in Gastric Cancer Patients Who Receive Curative Treatment</title><title>Journal of gastrointestinal cancer</title><addtitle>J Gastrointest Canc</addtitle><addtitle>J Gastrointest Cancer</addtitle><description>Background
We investigated the clinical influence of the prealbumin level on the gastric cancer survival and recurrence after curative treatment.
Methods
This study included 447 patients who underwent curative treatment for gastric cancer between 2013 and 2017. The risk factors for the overall survival (OS) and recurrence-free survival (RFS) were identified.
Results
A prealbumin level of 20 mg/dl was regarded as the optimal point of classification, considering the 3- and 5-year survival rates. The OS rates at 3 and 5 years after surgery were 80.7% and 65.0% in the low-prealbumin group, respectively, and 93.1% and 87.9% in the high-prealbumin group, respectively, a statistically significant difference (
p
< 0.001). The RFS rates at 3 and 5 years after surgery were 71.7% and 68.0% in the low-prealbumin group, respectively, and 90.1% and 84.7% in the high-prealbumin group, respectively, a statistically significant difference (
p
= 0.031). A multivariate analysis demonstrated that the prealbumin level was a significant independent risk factor for the OS and RFS. In addition, the rate of introduction of adjuvant chemotherapy was significantly lower and the frequency of peritoneal recurrence and lymph node recurrence significantly higher in the low-prealbumin group than in the high-prealbumin group.
Conclusion
Prealbumin is a risk factor for the survival in patients who undergo curative treatment for gastric cancer. It is necessary to develop an effective plan of perioperative care and surgical strategy according to the prealbumin level.</description><subject>Cancer Research</subject><subject>Clinical Relevance</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Lymph Nodes</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neoplasm Recurrence, Local - epidemiology</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Prealbumin</subject><subject>Prognosis</subject><subject>Radiotherapy</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Stomach Neoplasms - surgery</subject><issn>1941-6628</issn><issn>1941-6636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9UctO5DAQtFaLlucPcEA-7iXgthMnOa1QxALSSCAe4mg5nvaMUeKAnQzi79cwMFounFzuqq5udRFyCOwYGCtPInDG64xxyNK3LLOXH2QH6hwyKYX8ucG82ia7MT4yJvMC4BfZFnnNQZawQxZN57wzuqO3buGdTdAbpIOl4xLpdUDdtVPvPJ3hCjuawLmOY3CGNm_CQK_16NCPkT4sB3qDBt0KaTOFVE7gLhmMfeL3yZbVXcSDj3eP3P89u2sustnV-WVzOstMAWLM0FY8Z3Mmai0EYsEM5hW3Jq9kJSojC9Zi0bbCmlaYKq9LYy0A48bqOcPWiD3yZ-37NLU9zk0aHXSnnoLrdXhVg3bqK-PdUi2GlQIGFa-5TA6_PxzC8DxhHFXvosGu0x6HKSouAWQBeVEkKV9LTRhiDGg3c4Cpt4jUOiKVIlLvEamX1HT0_4abls9MkkCsBTFRfoFBPQ5T8Olq39n-A-b3n3c</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Aoyama, Toru</creator><creator>Nakazono, Masato</creator><creator>Segami, Kenki</creator><creator>Nagasawa, Shinsuke</creator><creator>Kano, Kazuki</creator><creator>Hara, Kentaro</creator><creator>Maezawa, Yukio</creator><creator>Hashimoto, Itaru</creator><creator>Suematsu, Hideaki</creator><creator>Watanabe, Hayato</creator><creator>Komori, Keisuke</creator><creator>Tamagawa, Hiroshi</creator><creator>Yukawa, Norio</creator><creator>Rino, Yasushi</creator><creator>Ogata, Takashi</creator><creator>Oshima, Takashi</creator><general>Springer US</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20230301</creationdate><title>Clinical Significance of the Prealbumin Level in Gastric Cancer Patients Who Receive Curative Treatment</title><author>Aoyama, Toru ; Nakazono, Masato ; Segami, Kenki ; Nagasawa, Shinsuke ; Kano, Kazuki ; Hara, Kentaro ; Maezawa, Yukio ; Hashimoto, Itaru ; Suematsu, Hideaki ; Watanabe, Hayato ; Komori, Keisuke ; Tamagawa, Hiroshi ; Yukawa, Norio ; Rino, Yasushi ; Ogata, Takashi ; Oshima, Takashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-ef8240d039a33ee50ce482fc486838c650be5bb3fcb3c8497cff1102cfad0ebc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cancer Research</topic><topic>Clinical Relevance</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Lymph Nodes</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neoplasm Recurrence, Local - epidemiology</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Prealbumin</topic><topic>Prognosis</topic><topic>Radiotherapy</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Stomach Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aoyama, Toru</creatorcontrib><creatorcontrib>Nakazono, Masato</creatorcontrib><creatorcontrib>Segami, Kenki</creatorcontrib><creatorcontrib>Nagasawa, Shinsuke</creatorcontrib><creatorcontrib>Kano, Kazuki</creatorcontrib><creatorcontrib>Hara, Kentaro</creatorcontrib><creatorcontrib>Maezawa, Yukio</creatorcontrib><creatorcontrib>Hashimoto, Itaru</creatorcontrib><creatorcontrib>Suematsu, Hideaki</creatorcontrib><creatorcontrib>Watanabe, Hayato</creatorcontrib><creatorcontrib>Komori, Keisuke</creatorcontrib><creatorcontrib>Tamagawa, Hiroshi</creatorcontrib><creatorcontrib>Yukawa, Norio</creatorcontrib><creatorcontrib>Rino, Yasushi</creatorcontrib><creatorcontrib>Ogata, Takashi</creatorcontrib><creatorcontrib>Oshima, Takashi</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of gastrointestinal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aoyama, Toru</au><au>Nakazono, Masato</au><au>Segami, Kenki</au><au>Nagasawa, Shinsuke</au><au>Kano, Kazuki</au><au>Hara, Kentaro</au><au>Maezawa, Yukio</au><au>Hashimoto, Itaru</au><au>Suematsu, Hideaki</au><au>Watanabe, Hayato</au><au>Komori, Keisuke</au><au>Tamagawa, Hiroshi</au><au>Yukawa, Norio</au><au>Rino, Yasushi</au><au>Ogata, Takashi</au><au>Oshima, Takashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Significance of the Prealbumin Level in Gastric Cancer Patients Who Receive Curative Treatment</atitle><jtitle>Journal of gastrointestinal cancer</jtitle><stitle>J Gastrointest Canc</stitle><addtitle>J Gastrointest Cancer</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>54</volume><issue>1</issue><spage>27</spage><epage>34</epage><pages>27-34</pages><issn>1941-6628</issn><eissn>1941-6636</eissn><abstract>Background
We investigated the clinical influence of the prealbumin level on the gastric cancer survival and recurrence after curative treatment.
Methods
This study included 447 patients who underwent curative treatment for gastric cancer between 2013 and 2017. The risk factors for the overall survival (OS) and recurrence-free survival (RFS) were identified.
Results
A prealbumin level of 20 mg/dl was regarded as the optimal point of classification, considering the 3- and 5-year survival rates. The OS rates at 3 and 5 years after surgery were 80.7% and 65.0% in the low-prealbumin group, respectively, and 93.1% and 87.9% in the high-prealbumin group, respectively, a statistically significant difference (
p
< 0.001). The RFS rates at 3 and 5 years after surgery were 71.7% and 68.0% in the low-prealbumin group, respectively, and 90.1% and 84.7% in the high-prealbumin group, respectively, a statistically significant difference (
p
= 0.031). A multivariate analysis demonstrated that the prealbumin level was a significant independent risk factor for the OS and RFS. In addition, the rate of introduction of adjuvant chemotherapy was significantly lower and the frequency of peritoneal recurrence and lymph node recurrence significantly higher in the low-prealbumin group than in the high-prealbumin group.
Conclusion
Prealbumin is a risk factor for the survival in patients who undergo curative treatment for gastric cancer. It is necessary to develop an effective plan of perioperative care and surgical strategy according to the prealbumin level.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>34921671</pmid><doi>10.1007/s12029-021-00777-w</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1941-6628 |
| ispartof | Journal of gastrointestinal cancer, 2023-03, Vol.54 (1), p.27-34 |
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| source | Springer Link |
| subjects | Cancer Research Clinical Relevance Gastroenterology Humans Internal Medicine Lymph Nodes Medicine Medicine & Public Health Neoplasm Recurrence, Local - epidemiology Oncology Original Research Prealbumin Prognosis Radiotherapy Retrospective Studies Risk Factors Stomach Neoplasms - surgery |
| title | Clinical Significance of the Prealbumin Level in Gastric Cancer Patients Who Receive Curative Treatment |
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