WHSC1 is involved in DNA damage, cellular senescence and immune response in hepatocellular carcinoma progression

Wolf–Hirschhorn syndrome candidate 1 (WHSC1) is a transcriptional regulatory protein that encodes a histone methyltransferase to control H3K36me2 modification. WHSC1 was upregulated and associated with poor prognosis in HCC. The elevated WHSC1 likely due to the alterations of DNA methylation or RNA...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2023-05, Vol.27 (10), p.1436-1441
Main Authors: Yan, Jia, Zhang, Ming Yang, Lin, Jing, Li, Ke Xin, Zhao, Zhi Min, Gao, Yu Min, Deng, Xiu Ling, Wang, Chang Shan, Wang, Hai Sheng
Format: Article
Language:English
Subjects:
Biomarkers
Carcinoma, Hepatocellular - genetics
CD4 antigen
Cell cycle
Cell growth
Cellular Senescence - genetics
Chemokines
Chromatin
DNA damage
DNA Damage - genetics
DNA methylation
DNA repair
Epigenetics
Gene expression
Hepatocellular carcinoma
Histone methyltransferase
Histones - genetics
Histones - metabolism
Humans
Immunity
Immunotherapy
Liver cancer
Liver Neoplasms - genetics
Macrophages
Medical prognosis
Neutrophils
Prognosis
Proteins
Repressor Proteins - genetics
RNA modification
Senescence
Short Communication
Survival analysis
Therapeutic targets
Transcription factors
Transcription Factors - metabolism
Wound healing
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Summary:Wolf–Hirschhorn syndrome candidate 1 (WHSC1) is a transcriptional regulatory protein that encodes a histone methyltransferase to control H3K36me2 modification. WHSC1 was upregulated and associated with poor prognosis in HCC. The elevated WHSC1 likely due to the alterations of DNA methylation or RNA modification. WHSC1 perhaps form a chromatin cross talk with H3K27me3 and DNA methylation to regulate transcription factors expression in HCC. Functional analysis indicated that WHSC1 was involved in DNA damage repair, cell cycle, cellular senescence and immune regulations. Furthermore, WHSC1 was associated with the infiltrating levels of B cell, CD4+, Tregs and macrophage cells. Therefore, our findings suggested that WHSC1 might function as a promotor regulator to affect the development and progression of HCC. Thus, WHSC1 could be a potential biomarker in predicting the prognosis and therapeutic target for patients with HCC.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.17743