Unique cytologic and imaging features of a lumbosacral oligodendroglioma in a cat

• Published in: Journal of veterinary diagnostic investigation 2023-05, Vol.35 (3), p.289-294
• Main Authors: Korff, Courtney P., Chu, Shelley A., Percival, Aaron J., Nelissen, Sophie, Wood, Jonathan H., Davies, Emma, Miller, Andrew D., Newman, Ashleigh W.
• Format: Article
• Language: English
• Subjects: Animals; Brief Reports; Cat Diseases - diagnostic imaging; Catalase; Cats; Laminectomy - veterinary; Lymphoma - veterinary; Magnetic Resonance Imaging - veterinary; Male; Oligodendroglioma - diagnostic imaging; Oligodendroglioma - veterinary
• ISSN: 1040-6387; 1943-4936
• DOI: 10.1177/10406387231166132

A 12-y-old castrated male domestic longhaired cat had progressive paraparesis and neurolocalization of L4–S3. MRI revealed a circumscribed intradural-extraparenchymal mass from L5 to S1 that was T2 and short tau inversion recovery hyperintense and strongly contrast-enhancing. Cytologic interpretation of a blind fine-needle aspirate obtained through the L5–L6 space was a tumor of probable mesenchymal origin. A pair of suspect neoplastic cells was seen on a cytocentrifuged preparation of the atlanto-occipital CSF sample, despite a normal nucleated cell count (0 × 106/L) and total protein (0.11 g/L) with only 3 RBCs × 106/L. Clinical signs progressed despite increasing doses of prednisolone and cytarabine arabinoside. Repeat MRI on day 162 demonstrated tumor progression from L4 to Cd2 vertebral segments with intraparenchymal extension. Surgical tumor debulking was attempted, but an L4–S1 dorsal laminectomy revealed diffusely abnormal neuroparenchyma. Intraoperative cryosection favored lymphoma, and the cat was euthanized intraoperatively 163 d following presentation. Postmortem examination was performed, and the final diagnosis was a high-grade oligodendroglioma. This case illustrates the cytologic, cryosection, and MRI features of a unique clinical presentation of oligodendroglioma.