Research progress of ophthalmic preparations of immunosuppressants

Immune ophthalmopathy is a collection of autoimmune eye diseases. Immunosuppressants are drugs that can inhibit the body's immune response. Considering drug side effects such as hepatorenal toxicity and the unique structure of the eye, incorporating immunosuppressants into ophthalmic nanodrug d...

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Bibliographic Details
Published in:Drug delivery 2023-12, Vol.30 (1), p.2175925-2175925
Main Authors: Liu, Ye, Xu, Haonan, Yan, Na, Tang, Zhan, Wang, Qiao
Format: Article
Language:English
Subjects:
Administration, Ophthalmic
Anemia
Antibiotics
Cancer therapies
Cataracts
Corneal transplantation
Cytokines
Diabetes
Drug delivery systems
Drug Delivery Systems - methods
Drugs
Edema
Eye
Eye diseases
Eye Diseases - drug therapy
Glaucoma
Humans
Hyperlipidemia
Hypertension
immune eye disease
Immunosuppressant
Immunosuppressive agents
Immunosuppressive Agents - pharmacology
Liposomes - pharmacology
Macular degeneration
Maternal & child health
Metabolic disorders
nano-delivery system
Nanoparticles
ophthalmic
Ophthalmic Solutions - chemistry
Pharmacy
Steroids
Toxicity
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Summary:Immune ophthalmopathy is a collection of autoimmune eye diseases. Immunosuppressants are drugs that can inhibit the body's immune response. Considering drug side effects such as hepatorenal toxicity and the unique structure of the eye, incorporating immunosuppressants into ophthalmic nanodrug delivery systems, such as microparticles, nanoparticles, liposomes, micelles, implants, and in situ gels, has the advantages of improving solubility, increasing bioavailability, high eye-target specificity, and reducing side effects. This study reviews recent research and applications of this aspect to provide a reference for the development of an ophthalmic drug delivery system.
ISSN:1071-7544
1521-0464
DOI:10.1080/10717544.2023.2175925