Sex-Based Contributors to and Consequences of Post-traumatic Stress Disorder

Purpose of Review Women are twice as likely to develop post-traumatic stress disorder (PTSD) compared to men after a traumatic experience. The purpose of this mini review was to explore recent research on biological contributors to this sex difference. Recent Findings We identified 51 studies publis...

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Bibliographic Details
Published in:Current psychiatry reports 2023-05, Vol.25 (5), p.233-245
Main Authors: Hiscox, Lucy V., Sharp, Tamsin H., Olff, Miranda, Seedat, Soraya, Halligan, Sarah L.
Format: Article
Language:English
Subjects:
Brain
Brain research
Comorbidity
Emotions
Epigenetics
Female
Females
Gender differences
Gene expression
Genomes
Hormones
Humans
Leukocytes
Male
Males
Medicine
Medicine & Public Health
Neuropeptides
Post traumatic stress disorder
Psychiatry
Sex Characteristics
Stress Disorders, Post-Traumatic - epidemiology
Topical Collection on Sex and Gender Issues in Behavioral Health
Women
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Summary:Purpose of Review Women are twice as likely to develop post-traumatic stress disorder (PTSD) compared to men after a traumatic experience. The purpose of this mini review was to explore recent research on biological contributors to this sex difference. Recent Findings We identified 51 studies published since 2019. Studies found that beyond the influence of sex on the prevalence and symptoms of PTSD, there is evidence for and against sex-based differences in genetic and epigenetic factors ( n  = 8), brain structure and function ( n  = 11), neuroendocrine and inflammatory responses ( n  = 5), and in the role of sleep on emotional memory processing ( n  = 1). Sex differences were also observed in recovery and during PTSD treatment ( n  = 16). Finally, there is emerging evidence of sex-differentiated risk for medical and psychiatric comorbidities in PTSD ( n  = 10). Summary Rapid advances are being made using integrated multidisciplinary approaches to understand why females are at a heightened risk for developing PTSD.
ISSN:1523-3812
1535-1645
DOI:10.1007/s11920-023-01421-z