Vancomycin-Induced Hemolytic Anemia

Drug-induced hemolytic anemia is rare and can occur either by an immune-mediated mechanism or a non-immune-mediated mechanism. The drugs most frequently associated with immune-mediated hemolysis are penicillins and cephalosporins. It is usually difficult to distinguish drug-induced hemolysis from ot...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2023-05, Vol.15 (5), p.e39191
Main Authors: Siddiqui, Fakeha, Cheema, Ahmad, Kamran, Amir
Format: Article
Language:English
Subjects:
Abdomen
Allergy/Immunology
Anemia
Antibiotics
Antibodies
Blood
Blood transfusions
Case reports
Dehydrogenases
Drugs
Hematology
Hemoglobin
Internal Medicine
Joint replacement surgery
Knee
Patients
Penicillin
Phosphatase
Proteins
Steroids
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Summary:Drug-induced hemolytic anemia is rare and can occur either by an immune-mediated mechanism or a non-immune-mediated mechanism. The drugs most frequently associated with immune-mediated hemolysis are penicillins and cephalosporins. It is usually difficult to distinguish drug-induced hemolysis from other more common causes of hemolysis; therefore, a high index of clinical suspicion is required to make the diagnosis. In this case report, we present a case of vancomycin-induced immune hemolytic anemia in a 75-year-old patient who developed hemolytic anemia after starting vancomycin for joint infection. Hematological parameters improved after the discontinuation of vancomycin. Mechanism and management of drug-induced immune hemolytic anemia are also reviewed in this report.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.39191