Association between an oxidative balance score and mortality: a prospective analysis in the SUN cohort

Purpose We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause death and cause-specific mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates. Methods Using baseline in...

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Published in:European journal of nutrition 2023-06, Vol.62 (4), p.1667-1680
Main Authors: Talavera-Rodriguez, Irene, Fernandez-Lazaro, Cesar I., Hernández-Ruiz, Ángela, Hershey, Maria S., Galarregui, Cristina, Sotos-Prieto, Mercedes, de la Fuente-Arrillaga, Carmen, Martínez-González, Miguel Ángel, Ruiz-Canela, Miguel
Format: Article
Language:English
Subjects:
Adult
Antioxidants
Antioxidants - metabolism
Body mass index
Cancer
Cardiovascular Diseases
Chemistry
Chemistry and Materials Science
Diet
Female
Heme
Humans
Male
Mortality
NCT
NCT02669602
Neoplasms
Nutrition
Original Contribution
Oxidative Stress
Physical activity
Polyphenols
Risk Factors
Selenium
Spain - epidemiology
Vitamins
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Summary:Purpose We aimed to prospectively investigate the association of an overall oxidative balance score (OBS) with all-cause death and cause-specific mortality among participants in the Seguimiento Universidad de Navarra (SUN) Study, a Mediterranean cohort of Spanish graduates. Methods Using baseline information on 12 a priori selected dietary and non-dietary lifestyle pro- and antioxidants exposures—vitamins C and E, β-carotenes, selenium, zinc, heme iron, polyphenols, total antioxidant capacity, body mass index, alcohol, smoking, and physical activity—we constructed an equally weighted OBS categorized into quartiles, with higher scores representing greater antioxidant balance. Cox proportional hazards models were fitted to evaluate the association between the OBS and mortality. Results A total of 18,561 participants (mean [SD] age, 38.5 [12.4] years; 40.8% males) were included in the analysis. During a median follow-up of 12.2 years (interquartile range 8.3–14.9), 421 deaths were identified, including 80 deaths from cardiovascular disease (CVD), 215 from cancer, and 126 from other causes. After adjustment for potential confounders, the hazard ratios and 95% confidence interval (CIs) between the highest quartile (predominance of antioxidants) vs. the lowest quartile (reference category) were 0.35 (95% CI 0.22–0.54, P -trend 
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-023-03099-8