Preterm birth alters the feeding-induced activation of Akt signaling in the muscle of neonatal piglets

Background Postnatal lean mass accretion is commonly reduced in preterm infants. This study investigated mechanisms involved in the blunted feeding-induced activation of Akt in the skeletal muscle of preterm pigs that contributes to lower protein synthesis rates. Methods On day 3 following cesarean...

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Bibliographic Details
Published in:Pediatric research 2023-06, Vol.93 (7), p.1891-1898
Main Authors: Suryawan, Agus, Rudar, Marko, Naberhuis, Jane K., Fiorotto, Marta L., Davis, Teresa A.
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Basic Science Article
Cesarean Section
Female
Hogs
Humans
Infant, Newborn
Infant, Premature
Medicine
Medicine & Public Health
Muscle, Skeletal - metabolism
Musculoskeletal system
Pediatric Surgery
Pediatrics
Phosphotransferases (Phosphate Group Acceptor) - metabolism
Pregnancy
Premature babies
Premature birth
Premature Birth - metabolism
Protein synthesis
Proto-Oncogene Proteins c-akt - metabolism
Swine
TOR Serine-Threonine Kinases - metabolism
Ubiquitins - metabolism
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Summary:Background Postnatal lean mass accretion is commonly reduced in preterm infants. This study investigated mechanisms involved in the blunted feeding-induced activation of Akt in the skeletal muscle of preterm pigs that contributes to lower protein synthesis rates. Methods On day 3 following cesarean section, preterm and term piglets were fasted or fed an enteral meal. Activation of Akt signaling pathways in skeletal muscle was determined. Results Akt1 and Akt2, but not Akt3, phosphorylation were lower in the skeletal muscle of preterm than in term pigs ( P  
ISSN:0031-3998
1530-0447
DOI:10.1038/s41390-022-02382-4