Cumulative Mycobacterium tuberculosis Infection Incidence (Measured Primarily by Tuberculin Skin Test) Among Infants With Human Immunodeficiency Virus Exposure: Observational Follow-up of an Isoniazid Prophylaxis Trial

Abstract   Cumulative 24-month Mycobacterium tuberculosis infection incidence (measured primarily by tuberculin skin test [TST]) was high among human immunodeficiency virus exposed but uninfected infants (8.7 [95% confidence interval, 6.3–11.9] per 100 person-years). Trend for decreased TST positivi...

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Bibliographic Details
Published in:Clinical infectious diseases 2022-12, Vol.75 (12), p.2253-2256
Main Authors: LaCourse, Sylvia M, Escudero, Jaclyn N, Mecha, Jerphason, Warr, A J, Richardson, Barbra A, Carimo, Naziat, Cranmer, Lisa M, Maleche-Obimbo, Elizabeth, Matemo, Daniel, Kinuthia, John, Hawn, Thomas R, John-Stewart, Grace
Format: Article
Language:English
Subjects:
Antitubercular Agents - therapeutic use
Brief Report
Child, Preschool
Follow-Up Studies
HIV
HIV Infections - drug therapy
Humans
Incidence
Infant
Isoniazid - therapeutic use
Mycobacterium tuberculosis
Tuberculin Test
Tuberculosis - epidemiology
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Summary:Abstract   Cumulative 24-month Mycobacterium tuberculosis infection incidence (measured primarily by tuberculin skin test [TST]) was high among human immunodeficiency virus exposed but uninfected infants (8.7 [95% confidence interval, 6.3–11.9] per 100 person-years). Trend for decreased TST positivity among infants at trial end (12 months postenrollment) randomized to isoniazid at 6 weeks of age was not sustained through observational follow-up to 24 months of age. Clinical Trials Registration NCT02613169.
ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/ciac393