Exploring the acute effects of running on cerebral blood flow and food cue reactivity in healthy young men using functional magnetic resonance imaging

• Published in: Human brain mapping 2023-06, Vol.44 (9), p.3815-3832
• Main Authors: Thackray, Alice E., Hinton, Elanor C., Alanazi, Turki M., Dera, Abdulrahman M., Fujihara, Kyoko, Hamilton‐Shield, Julian P., King, James A., Lithander, Fiona E., Miyashita, Masashi, Thompson, Julie, Morgan, Paul S., Davies, Melanie J., Stensel, David J.
• Format: Article
• Language: English
• Subjects: Acute effects; Amygdala; Appetite; Blood flow; Body fat; Brain; Brain - physiology; Caudate-putamen; Cerebral blood flow; Cerebrovascular Circulation - physiology; Cortex (frontal); Cross-Over Studies; Cues; Eating behavior; Exercise; fMRI; Food; food cue reactivity; Functional magnetic resonance imaging; Hippocampus; Humans; Labeling; Laboratories; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Maximum oxygen consumption; Metabolism; Neostriatum; Neuroimaging; Oxygen; Oxygen consumption; Oxygen uptake; Physical fitness; Physical training; Questionnaires; Ratings; Running; Spin labeling; Substantia grisea; Time dependence; Variability; Visual stimuli
• ISSN: 1065-9471; 1097-0193
• DOI: 10.1002/hbm.26314

Acute exercise suppresses appetite and alters food‐cue reactivity, but the extent exercise‐induced changes in cerebral blood flow (CBF) influences the blood‐oxygen‐level‐dependent (BOLD) signal during appetite‐related paradigms is not known. This study examined the impact of acute running on visual food‐cue reactivity and explored whether such responses are influenced by CBF variability. In a randomised crossover design, 23 men (mean ± SD: 24 ± 4 years, 22.9 ± 2.1 kg/m2) completed fMRI scans before and after 60 min of running (68% ± 3% peak oxygen uptake) or rest (control). Five‐minute pseudo‐continuous arterial spin labelling fMRI scans were conducted for CBF assessment before and at four consecutive repeat acquisitions after exercise/rest. BOLD‐fMRI was acquired during a food‐cue reactivity task before and 28 min after exercise/rest. Food‐cue reactivity analysis was performed with and without CBF adjustment. Subjective appetite ratings were assessed before, during and after exercise/rest. Exercise CBF was higher in grey matter, the posterior insula and in the region of the amygdala/hippocampus, and lower in the medial orbitofrontal cortex and dorsal striatum than control (main effect trial p ≤ .018). No time‐by‐trial interactions for CBF were identified (p ≥ .087). Exercise induced moderate‐to‐large reductions in subjective appetite ratings (Cohen's d = 0.53–0.84; p ≤ .024) and increased food‐cue reactivity in the paracingulate gyrus, hippocampus, precuneous cortex, frontal pole and posterior cingulate gyrus. Accounting for CBF variability did not markedly alter detection of exercise‐induced BOLD signal changes. Acute running evoked overall changes in CBF that were not time dependent and increased food‐cue reactivity in regions implicated in attention, anticipation of reward, and episodic memory independent of CBF. We investigated the impact of a single running bout on cerebral blood flow (CBF) and food cue reactivity using functional magnetic resonance imaging (fMRI) in healthy men. Running did not alter the time‐course of grey matter or regional CBF up to 30 min after exercise cessation but increased food cue reactivity in brain regions implicated in attention, reward and episodic memory retrieval. Exercise‐related BOLD signal changes were detected in the presence of underlying CBF.