A Comparative Analysis of Effectiveness of Recombinant Interleukin-11 Versus Papaya Leaf Extract for Treatment of Thrombocytopenia: A Review

• Published in: Indian journal of clinical biochemistry 2023-07, Vol.38 (3), p.297-304
• Main Authors: Mishra, K. P., Bakshi, Jyotsana, Sharma, Gitika, Singh, Somnath, Panjwani, Usha
• Format: Article
• Language: English
• Subjects: Biochemistry; Biomedical and Life Sciences; Blood clot; Blood coagulation; Blood platelets; Cancer; Carica papaya; Chemistry/Food Science; Chemotherapy; Comparative analysis; Corticosteroids; Cytokines; Dengue fever; Dengue viruses; Drug approval; Drug therapy; Health aspects; Hemostasis; Interleukin 11; Interleukins; Leaves; Life Sciences; Medicine, Botanic; Medicine, Herbal; Microbiology; Pathology; Plant extracts; Platelets; Review; Review Article; Side effects; Splenectomy; Thrombocytopenia; Thrombosis; Transfusion; Virus diseases
• ISSN: 0970-1915; 0974-0422
• DOI: 10.1007/s12291-022-01097-x

Platelets or thrombocytes play an important role in thrombosis and maintaining hemostasis. Thrombocytes help in forming blood clots at the site of the wound. When the level of platelets decreases, uncontrolled bleeding occurs which can result in mortality. A decrease in the blood platelet level is known as thrombocytopenia which can be caused due to various reasons. A variety of treatment options are available for thrombocytopenia like platelet transfusion, splenectomy, platelet management with various types of corticosteroids, and recombinant interleukin-11 (rhIL-11). The use of rhIL-11 is approved by FDA for the treatment of thrombocytopenia. rhIL-11 is a recombinant cytokine that is administered to patients suffering from chemotherapy-induced thrombocytopenia as it enhances megakaryocytic proliferation which aids in platelet production. But this treatment has various side effects and is costly. Hence, there is a crucial need to identify cost-effective alternative strategies that present no side effects. The majority of the population in low-income countries requires a functional and cost-effective treatment for low thrombocyte count. Carica papaya is a tropical herbaceous plant that has been reported in recovering low platelet count during dengue virus infection. Even though multiple benefits of the Carica papaya leaf extract (CPLE) are popular, the active compound present in it, which mediates these benefits, remains to be identified. This review aims to highlight the different aspects of rhIL-11 and CPLE-induced platelet counts and their limitations and benefits in the treatment of thrombocytopenia. The literature related to the treatment of thrombocytopenia using rhIL-11 and CPLE from 1970 to 2022 was searched using PubMed and Google Scholar databases with the keywords Recombinant Interleukin-11, Papaya Leaf Extract, Thrombocytopenia, and Platelets.