Tumorigenic adenovirus 12 cells evade NK cell lysis by reducing the expression of NKG2D ligands

Highlights ► Tumorigenic Ad12 cells are more resistant to NK lysis compared to non-tumorigenic Ad5 cells, despite their reduced MHC I expression. ► The expression of NKG2D ligands on the surface of tumorigenic Ad12 cells is diminished compared to non-tumorigenic Ad5 cells. ► Reduced surface expressi...

Full description

Saved in:
Bibliographic Details
Published in:Immunology letters 2012-05, Vol.144 (1), p.16-23
Main Authors: Heyward, Christa Y, Patel, Rajen, Mace, Emily M, Grier, Jennifer T, Guan, Hancheng, Makrigiannis, Andrew P, Orange, Jordan S, Ricciardi, Robert P
Format: Article
Language:English
Subjects:
Adenovirus 12
Adenoviruses, Human - pathogenicity
Adenoviruses, Human - physiology
Allergy and Immunology
Animals
Brain - cytology
Brain - virology
Cell Line
Cell Transformation, Neoplastic
Cell Transformation, Viral
Cytotoxicity, Immunologic - immunology
Humans
Immune evasion
Kidney - cytology
Kidney - virology
Killer Cells, Natural - immunology
Killer Cells, Natural - metabolism
Ligands
Mice
Mice, Inbred BALB C
Mice, SCID
NK Cell Lectin-Like Receptor Subfamily K - genetics
NK Cell Lectin-Like Receptor Subfamily K - metabolism
NKG2D ligand
Rats
RNA, Messenger - genetics
Tumorigenesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights ► Tumorigenic Ad12 cells are more resistant to NK lysis compared to non-tumorigenic Ad5 cells, despite their reduced MHC I expression. ► The expression of NKG2D ligands on the surface of tumorigenic Ad12 cells is diminished compared to non-tumorigenic Ad5 cells. ► Reduced surface expression of NKG2D ligands on tumorigenic Ad12 cells correlates with their reduced mRNA expression.
ISSN:0165-2478
1879-0542
DOI:10.1016/j.imlet.2012.03.001