Treatment of pulmonary aspergilloma with itraconazole

In a 12 month open study of itraconazole in pulmonary aspergilloma nine patients received oral itraconazole 200 mg daily for six months followed by further itraconazole or observation for a further six months. There was no change in the serum IgG specific for Aspergillus fumigatus (mean (SE) change...

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Bibliographic Details
Published in:Thorax 1991-11, Vol.46 (11), p.839-841
Main Authors: Campbell, J H, Winter, J H, Richardson, M D, Shankland, G S, Banham, S W
Format: Article
Language:English
Subjects:
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antibodies, Fungal - analysis
Antifungal agents
Antifungal Agents - therapeutic use
Aspergillosis - diagnostic imaging
Aspergillosis - drug therapy
Aspergillus fumigatus - immunology
Biological and medical sciences
Female
Humans
Immunoglobulin G - analysis
Itraconazole
Ketoconazole - analogs & derivatives
Ketoconazole - therapeutic use
Lung - diagnostic imaging
Lung Diseases, Fungal - diagnostic imaging
Lung Diseases, Fungal - drug therapy
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Radiography
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Summary:In a 12 month open study of itraconazole in pulmonary aspergilloma nine patients received oral itraconazole 200 mg daily for six months followed by further itraconazole or observation for a further six months. There was no change in the serum IgG specific for Aspergillus fumigatus (mean (SE) change -4% (10%)) or symptoms of chronic cough and haemoptysis. In two of the three patients who continued treatment beyond six months symptoms and radiographic appearances improved and a temporary reduction in A fumigatus specific IgG occurred in one patient. Further experience of the effects of longer treatment are needed before oral itraconazole can be recommended for aspergilloma.
ISSN:0040-6376
1468-3296
DOI:10.1136/thx.46.11.839