Identification of Proteins Using Supramolecular Gold Nanoparticle‐Dye Sensor Arrays

The rapid detection of proteins is very important in the early diagnosis of diseases. Gold nanoparticles (AuNPs) can be engineered to bind biomolecules efficiently and differentially. Cross‐reactive sensor arrays have high sensitivity for sensing proteins using differential interactions between sens...

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Bibliographic Details
Published in:Analysis & sensing 2023-05, Vol.3 (3), p.n/a
Main Authors: Jiang, Mingdi, Gupta, Aarohi, Zhang, Xianzhi, Nath Chattopadhyay, Aritra, Fedeli, Stefano, Huang, Rui, Yang, Junwhee, Rotello, Vincent M.
Format: Article
Language:English
Subjects:
Biomolecules
Dyes
Gold
gold nanoparticles
human serum
Nanoparticles
Proteins
Quenching
sensor array
Sensor arrays
surface charge
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Summary:The rapid detection of proteins is very important in the early diagnosis of diseases. Gold nanoparticles (AuNPs) can be engineered to bind biomolecules efficiently and differentially. Cross‐reactive sensor arrays have high sensitivity for sensing proteins using differential interactions between sensor elements and bioanalytes. A new sensor array was fabricated using surface‐charged AuNPs with dyes supramolecularly encapsulated into the AuNP monolayer. The fluorescence of dyes is partially quenched by the AuNPs and can be restored or further quenched due to the differential interactions between AuNPs with proteins. This sensing system enables the discrimination of proteins in both buffer and human serum, providing a potential tool for real‐world disease diagnostics. AuNP‐based sensor arrays were built using different surface‐charged AuNPs encapsulating dyes. Driven by differential interactions of surface‐charged AuNPs with proteins, this sensing platform can provide a robust tool to discriminate proteins in human serum for real‐world disease diagnosis.
ISSN:2629-2742
2629-2742
DOI:10.1002/anse.202200080