Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy?

Follicle-stimulating hormone (FSH), together with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), plays a fundamental role in human reproduction. The discovery of FSH and other gonadotropins was a defining moment in our understanding of reproduction and led to the development of man...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2023-05, Vol.24 (10), p.9020
Main Authors: Lispi, Monica, Humaidan, Peter, Bousfield, George R, D'Hooghe, Thomas, Ulloa-Aguirre, Alfredo
Format: Article
Language:English
Subjects:
Acids
Biological activity
Biological Products
Chorionic gonadotropin
Chorionic Gonadotropin - pharmacology
Female
Follicle Stimulating Hormone - pharmacology
Follicle Stimulating Hormone, Human - pharmacology
Follicle-stimulating hormone
Follicles
Glycoproteins
Gonadotropin
Gonadotropins
Heterogeneity
Hormones
Human reproduction
Humans
Infertility
Luteinizing hormone
Ovaries
Pharmacodynamics
Pharmacokinetics
Physiology
Pituitary (anterior)
Pituitary gland
Proteins
Reproduction
Review
Signal transduction
Treatment Outcome
Urine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c480t-7f6be27d1c12a260a1385cb11667b5943063f7e0eda5761d779b6c7d82855d1c3
cites cdi_FETCH-LOGICAL-c480t-7f6be27d1c12a260a1385cb11667b5943063f7e0eda5761d779b6c7d82855d1c3
container_end_page
container_issue 10
container_start_page 9020
container_title International journal of molecular sciences
container_volume 24
creator Lispi, Monica
Humaidan, Peter
Bousfield, George R
D'Hooghe, Thomas
Ulloa-Aguirre, Alfredo
description Follicle-stimulating hormone (FSH), together with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), plays a fundamental role in human reproduction. The discovery of FSH and other gonadotropins was a defining moment in our understanding of reproduction and led to the development of many treatments for infertility. In this regard, exogenous FSH has been used to treat infertility in women for decades. Today, several recombinant and highly purified urinary forms of FSH are used in medically assisted reproduction (MAR). However, differences in the macro- and micro-heterogeneity of FSH result in a variety of FSH glycoforms, with glycoform composition determining the bioactivity (or potency), pharmacokinetic/pharmacodynamic (PK/PD) profiles, and clinical efficacy of the different forms of FSH. This review illustrates how the structural heterogeneity of FSH glycoforms affects the biological activity of human FSH products, and why potency does not predict effects in humans in terms of PK, PD, and clinical response.
doi_str_mv 10.3390/ijms24109020
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10218858</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A752424942</galeid><sourcerecordid>A752424942</sourcerecordid><originalsourceid>FETCH-LOGICAL-c480t-7f6be27d1c12a260a1385cb11667b5943063f7e0eda5761d779b6c7d82855d1c3</originalsourceid><addsrcrecordid>eNptksFvFSEQxonR2Fq9eTabePHg1mFgYddLU5-tNWliE_XgibAs--SFhQq7Ju-_l2drfTWGw5Dh930wwxDynMIxYx28cZspI6fQAcIDckg5Yg0g5MO9_QF5kvMGABk23WNywCRyYIIfkm_n0XtnvK0_z25avJ5dWFcXMU0x2Oqdiz6undG-ukpxWMyc31bvo83VVZxtMNuStoMzc7XyLvzmzsaxRLM9eUoejdpn--w2HpGv52dfVhf15acPH1enl7XhLcy1HEVvUQ7UUNQoQFPWNqanVAjZNx1nINgoLdhBN1LQQcquF0YOLbZNU1TsiJzc-F4v_WQHY8OctFfXyU06bVXUTt0_Ce67WsefigLStm3a4vDq1iHFH4vNs5pcNtZ7HWxcssIWASiXYoe-_AfdxCWFUl-haHkto5z_pdbaW-XCGMvFZmeqTmWDHHnHsVDH_6HKGuzkTGn_6Er-nuD1jcCkmHOy412RFNRuFtT-LBT8xX5j7uA_n89-AXpjrb4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2819433144</pqid></control><display><type>article</type><title>Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy?</title><source>Publicly Available Content Database</source><source>PubMed Central</source><creator>Lispi, Monica ; Humaidan, Peter ; Bousfield, George R ; D'Hooghe, Thomas ; Ulloa-Aguirre, Alfredo</creator><creatorcontrib>Lispi, Monica ; Humaidan, Peter ; Bousfield, George R ; D'Hooghe, Thomas ; Ulloa-Aguirre, Alfredo</creatorcontrib><description>Follicle-stimulating hormone (FSH), together with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), plays a fundamental role in human reproduction. The discovery of FSH and other gonadotropins was a defining moment in our understanding of reproduction and led to the development of many treatments for infertility. In this regard, exogenous FSH has been used to treat infertility in women for decades. Today, several recombinant and highly purified urinary forms of FSH are used in medically assisted reproduction (MAR). However, differences in the macro- and micro-heterogeneity of FSH result in a variety of FSH glycoforms, with glycoform composition determining the bioactivity (or potency), pharmacokinetic/pharmacodynamic (PK/PD) profiles, and clinical efficacy of the different forms of FSH. This review illustrates how the structural heterogeneity of FSH glycoforms affects the biological activity of human FSH products, and why potency does not predict effects in humans in terms of PK, PD, and clinical response.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24109020</identifier><identifier>PMID: 37240364</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Acids ; Biological activity ; Biological Products ; Chorionic gonadotropin ; Chorionic Gonadotropin - pharmacology ; Female ; Follicle Stimulating Hormone - pharmacology ; Follicle Stimulating Hormone, Human - pharmacology ; Follicle-stimulating hormone ; Follicles ; Glycoproteins ; Gonadotropin ; Gonadotropins ; Heterogeneity ; Hormones ; Human reproduction ; Humans ; Infertility ; Luteinizing hormone ; Ovaries ; Pharmacodynamics ; Pharmacokinetics ; Physiology ; Pituitary (anterior) ; Pituitary gland ; Proteins ; Reproduction ; Review ; Signal transduction ; Treatment Outcome ; Urine</subject><ispartof>International journal of molecular sciences, 2023-05, Vol.24 (10), p.9020</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><rights>2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2023 by the authors. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c480t-7f6be27d1c12a260a1385cb11667b5943063f7e0eda5761d779b6c7d82855d1c3</citedby><cites>FETCH-LOGICAL-c480t-7f6be27d1c12a260a1385cb11667b5943063f7e0eda5761d779b6c7d82855d1c3</cites><orcidid>0000-0002-5632-7606 ; 0000-0002-9532-3886 ; 0000-0002-9920-3208</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2819433144/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2819433144?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37240364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lispi, Monica</creatorcontrib><creatorcontrib>Humaidan, Peter</creatorcontrib><creatorcontrib>Bousfield, George R</creatorcontrib><creatorcontrib>D'Hooghe, Thomas</creatorcontrib><creatorcontrib>Ulloa-Aguirre, Alfredo</creatorcontrib><title>Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy?</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Follicle-stimulating hormone (FSH), together with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), plays a fundamental role in human reproduction. The discovery of FSH and other gonadotropins was a defining moment in our understanding of reproduction and led to the development of many treatments for infertility. In this regard, exogenous FSH has been used to treat infertility in women for decades. Today, several recombinant and highly purified urinary forms of FSH are used in medically assisted reproduction (MAR). However, differences in the macro- and micro-heterogeneity of FSH result in a variety of FSH glycoforms, with glycoform composition determining the bioactivity (or potency), pharmacokinetic/pharmacodynamic (PK/PD) profiles, and clinical efficacy of the different forms of FSH. This review illustrates how the structural heterogeneity of FSH glycoforms affects the biological activity of human FSH products, and why potency does not predict effects in humans in terms of PK, PD, and clinical response.</description><subject>Acids</subject><subject>Biological activity</subject><subject>Biological Products</subject><subject>Chorionic gonadotropin</subject><subject>Chorionic Gonadotropin - pharmacology</subject><subject>Female</subject><subject>Follicle Stimulating Hormone - pharmacology</subject><subject>Follicle Stimulating Hormone, Human - pharmacology</subject><subject>Follicle-stimulating hormone</subject><subject>Follicles</subject><subject>Glycoproteins</subject><subject>Gonadotropin</subject><subject>Gonadotropins</subject><subject>Heterogeneity</subject><subject>Hormones</subject><subject>Human reproduction</subject><subject>Humans</subject><subject>Infertility</subject><subject>Luteinizing hormone</subject><subject>Ovaries</subject><subject>Pharmacodynamics</subject><subject>Pharmacokinetics</subject><subject>Physiology</subject><subject>Pituitary (anterior)</subject><subject>Pituitary gland</subject><subject>Proteins</subject><subject>Reproduction</subject><subject>Review</subject><subject>Signal transduction</subject><subject>Treatment Outcome</subject><subject>Urine</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNptksFvFSEQxonR2Fq9eTabePHg1mFgYddLU5-tNWliE_XgibAs--SFhQq7Ju-_l2drfTWGw5Dh930wwxDynMIxYx28cZspI6fQAcIDckg5Yg0g5MO9_QF5kvMGABk23WNywCRyYIIfkm_n0XtnvK0_z25avJ5dWFcXMU0x2Oqdiz6undG-ukpxWMyc31bvo83VVZxtMNuStoMzc7XyLvzmzsaxRLM9eUoejdpn--w2HpGv52dfVhf15acPH1enl7XhLcy1HEVvUQ7UUNQoQFPWNqanVAjZNx1nINgoLdhBN1LQQcquF0YOLbZNU1TsiJzc-F4v_WQHY8OctFfXyU06bVXUTt0_Ce67WsefigLStm3a4vDq1iHFH4vNs5pcNtZ7HWxcssIWASiXYoe-_AfdxCWFUl-haHkto5z_pdbaW-XCGMvFZmeqTmWDHHnHsVDH_6HKGuzkTGn_6Er-nuD1jcCkmHOy412RFNRuFtT-LBT8xX5j7uA_n89-AXpjrb4</recordid><startdate>20230519</startdate><enddate>20230519</enddate><creator>Lispi, Monica</creator><creator>Humaidan, Peter</creator><creator>Bousfield, George R</creator><creator>D'Hooghe, Thomas</creator><creator>Ulloa-Aguirre, Alfredo</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5632-7606</orcidid><orcidid>https://orcid.org/0000-0002-9532-3886</orcidid><orcidid>https://orcid.org/0000-0002-9920-3208</orcidid></search><sort><creationdate>20230519</creationdate><title>Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy?</title><author>Lispi, Monica ; Humaidan, Peter ; Bousfield, George R ; D'Hooghe, Thomas ; Ulloa-Aguirre, Alfredo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c480t-7f6be27d1c12a260a1385cb11667b5943063f7e0eda5761d779b6c7d82855d1c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Acids</topic><topic>Biological activity</topic><topic>Biological Products</topic><topic>Chorionic gonadotropin</topic><topic>Chorionic Gonadotropin - pharmacology</topic><topic>Female</topic><topic>Follicle Stimulating Hormone - pharmacology</topic><topic>Follicle Stimulating Hormone, Human - pharmacology</topic><topic>Follicle-stimulating hormone</topic><topic>Follicles</topic><topic>Glycoproteins</topic><topic>Gonadotropin</topic><topic>Gonadotropins</topic><topic>Heterogeneity</topic><topic>Hormones</topic><topic>Human reproduction</topic><topic>Humans</topic><topic>Infertility</topic><topic>Luteinizing hormone</topic><topic>Ovaries</topic><topic>Pharmacodynamics</topic><topic>Pharmacokinetics</topic><topic>Physiology</topic><topic>Pituitary (anterior)</topic><topic>Pituitary gland</topic><topic>Proteins</topic><topic>Reproduction</topic><topic>Review</topic><topic>Signal transduction</topic><topic>Treatment Outcome</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lispi, Monica</creatorcontrib><creatorcontrib>Humaidan, Peter</creatorcontrib><creatorcontrib>Bousfield, George R</creatorcontrib><creatorcontrib>D'Hooghe, Thomas</creatorcontrib><creatorcontrib>Ulloa-Aguirre, Alfredo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lispi, Monica</au><au>Humaidan, Peter</au><au>Bousfield, George R</au><au>D'Hooghe, Thomas</au><au>Ulloa-Aguirre, Alfredo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy?</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2023-05-19</date><risdate>2023</risdate><volume>24</volume><issue>10</issue><spage>9020</spage><pages>9020-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Follicle-stimulating hormone (FSH), together with luteinizing hormone (LH) and human chorionic gonadotropin (hCG), plays a fundamental role in human reproduction. The discovery of FSH and other gonadotropins was a defining moment in our understanding of reproduction and led to the development of many treatments for infertility. In this regard, exogenous FSH has been used to treat infertility in women for decades. Today, several recombinant and highly purified urinary forms of FSH are used in medically assisted reproduction (MAR). However, differences in the macro- and micro-heterogeneity of FSH result in a variety of FSH glycoforms, with glycoform composition determining the bioactivity (or potency), pharmacokinetic/pharmacodynamic (PK/PD) profiles, and clinical efficacy of the different forms of FSH. This review illustrates how the structural heterogeneity of FSH glycoforms affects the biological activity of human FSH products, and why potency does not predict effects in humans in terms of PK, PD, and clinical response.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>37240364</pmid><doi>10.3390/ijms24109020</doi><orcidid>https://orcid.org/0000-0002-5632-7606</orcidid><orcidid>https://orcid.org/0000-0002-9532-3886</orcidid><orcidid>https://orcid.org/0000-0002-9920-3208</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1422-0067
ispartof International journal of molecular sciences, 2023-05, Vol.24 (10), p.9020
issn 1422-0067
1661-6596
1422-0067
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10218858
source Publicly Available Content Database; PubMed Central
subjects Acids
Biological activity
Biological Products
Chorionic gonadotropin
Chorionic Gonadotropin - pharmacology
Female
Follicle Stimulating Hormone - pharmacology
Follicle Stimulating Hormone, Human - pharmacology
Follicle-stimulating hormone
Follicles
Glycoproteins
Gonadotropin
Gonadotropins
Heterogeneity
Hormones
Human reproduction
Humans
Infertility
Luteinizing hormone
Ovaries
Pharmacodynamics
Pharmacokinetics
Physiology
Pituitary (anterior)
Pituitary gland
Proteins
Reproduction
Review
Signal transduction
Treatment Outcome
Urine
title Follicle-Stimulating Hormone Biological Products: Does Potency Predict Clinical Efficacy?
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T01%3A02%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Follicle-Stimulating%20Hormone%20Biological%20Products:%20Does%20Potency%20Predict%20Clinical%20Efficacy?&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Lispi,%20Monica&rft.date=2023-05-19&rft.volume=24&rft.issue=10&rft.spage=9020&rft.pages=9020-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms24109020&rft_dat=%3Cgale_pubme%3EA752424942%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c480t-7f6be27d1c12a260a1385cb11667b5943063f7e0eda5761d779b6c7d82855d1c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2819433144&rft_id=info:pmid/37240364&rft_galeid=A752424942&rfr_iscdi=true