Association between Nontraditional Risk Factors and Calculated 10-Year Risk of Atherosclerotic Cardiovascular Disease in a Large General Population: Based on the Pars Cohort Study

• Published in: Journal of Tehran University Heart Center 2023, Vol.18 (1), p.24-32
• Main Authors: Ghorashi, Seyyed Mojtaba, Ahmadi, Pooria, Shahnazar Nezhad Khalesi, Reza, Fazeli, Amir, Molavi Vardanjani, Hossein, Salehi, Alireza, Omidi, Negar, Shams, Mesbah, Babaei, Amirhossein
• Format: Article
• Language: English
• Subjects: Arteriosclerosis; Atherosclerosis; Atherosclerotic; Cardiovascular Disease; Cardiovascular diseases; Cigarette smoking; Cohort analysis; Consumers; Educational Status; Health policy; Health risks; Heart diseases; Mathematical analysis; Mental disorders; Minority & ethnic groups; Narcotics; Opium; Original; Population studies; Population-based studies; Regression analysis; Risk Factors; Smoking; Tobacco
• ISSN: 1735-5370; 1735-8620; 2008-2371
• DOI: 10.18502/jthc.v18i1.12578

While the traditional risk factors of atherosclerotic cardiovascular disease (ASCVD) have been well-established, the evolving role of nontraditional risk factors is not apparent. This study aimed to evaluate the association between nontraditional risk factors and the calculated 10-year ASCVD risk in a general population. This cross-sectional study was conducted using the Pars Cohort Study data. All inhabitants of the Valashahr district in southern Iran, aged 40-75 years, were invited (2012-2014). Patients with a history of cardiovascular disease (CVD) were excluded. The demographic and lifestyle data were collected using a validated questionnaire. Multinomial logistic regression analysis was used to evaluate the association between the calculated 10-year ASCVD risk and the nontraditional risk factors of CVD, including marital status, ethnicity, educational level, tobacco and opiate consumption, physical inactivity, and psychiatric disorders. Of 9264 participants (mean age =52.2±9.0 y; 45.8% male), 7152 patients met the inclusion criteria. In total, 20.2%, 7.6%, 36.3%, 56.4%, and 46.2% of the population were cigarette smokers, opiate consumers, tobacco consumers, ethnically Fars, and illiterate, respectively. The prevalence rates of low, borderline, and intermediate-to-high 10-year ASCVD risks were 74.3%, 9.8%, and 16.2%, respectively. In multinomial regression, anxiety (adjusted odds ratio [aOR], 0.58; P