Correlation of glycemic control with salivary oxidative markers in subjects with prediabetes and diabetes: A cross-sectional study

Background and aims Rising levels of oxidative stress play an important role in the pathogenesis of type 2 diabetes mellitus. This study aimed to some assess salivary antioxidants in patients with type 2 diabetes, prediabetes, and healthy control. We also assessed the potential clinical relevance of...

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Bibliographic Details
Published in:Journal of diabetes and metabolic disorders 2023-02, Vol.22 (1), p.267-274
Main Authors: Pakfetrat, Atessa, Delavarian, Zahra, Mohebbi, Masoud, Hashemy, Seyed Isaac, Dalirsani, Zohreh, Ghazi, Ala, Esmaily, Habibollah, Hasani, Solmaz, Salari, Samaneh
Format: Article
Language:English
Subjects:
Antioxidants
Blood sugar
Diabetes
Diabetes therapy
Diabetics
Endocrinology
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Metabolic Diseases
Prediabetic state
Research Article
Superoxide
Type 2 diabetes
Uric acid
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Summary:Background and aims Rising levels of oxidative stress play an important role in the pathogenesis of type 2 diabetes mellitus. This study aimed to some assess salivary antioxidants in patients with type 2 diabetes, prediabetes, and healthy control. We also assessed the potential clinical relevance of salivary antioxidants with glycemic control. Methods This cross-sectional study included 30 prediabetes, 31 type 2 diabetes, and 39 sex-matched normoglycemic individuals. To assess the salivary oxidative status, we measured the levels of malondialdehyde (MDA), superoxide dismutase (SOD), the total antioxidant capacity (TAC), and uric acid (UA) by spectrophotometry. Results Salivary MDA levels were significantly higher in individuals with diabetes compared to prediabetes, and control groups (p = 0.001). MDA and SOD were significantly correlated with fasting blood sugar (FBS) and HbA1C (p 
ISSN:2251-6581
2251-6581
DOI:10.1007/s40200-022-01127-8