Anacardium occidentale leaves extract and riboceine mitigate hyperglycemia through anti-oxidative effects and modulation of some selected genes associated with diabetes

Background Diabetes mellitus (DM) is one of the leading causes of death globally and complications of DM have become a major health concern. Anacardium occidentale is a plant widely recognized for its hypoglycemic properties and traditionally used in developing nations as remedy for DM treatment. Ri...

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Bibliographic Details
Published in:Journal of diabetes and metabolic disorders 2022-12, Vol.22 (1), p.455-468
Main Authors: Ukwenya, Victor Okoliko, Alese, Margaret Olutayo, Ogunlade, Babatunde, Folorunso, Ibukun Mary, Omotuyi, Olaposi Idowu
Format: Article
Language:English
Subjects:
Analysis
Antioxidants
Blood sugar
Developing countries
Diabetes
Endocrinology
Gene expression
Genes
Genetic aspects
Genetic research
Hyperglycemia
Liver
Medicine
Medicine & Public Health
Medicine, Botanic
Medicine, Herbal
Metabolic Diseases
Research Article
Streptozocin
Urea
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Summary:Background Diabetes mellitus (DM) is one of the leading causes of death globally and complications of DM have become a major health concern. Anacardium occidentale is a plant widely recognized for its hypoglycemic properties and traditionally used in developing nations as remedy for DM treatment. Riboceine is a supplement that enhances production of glutathione and known for its vital role in supporting cellular function. This study was designed to evaluate the antidiabetic and antioxidant potential of riboceine and ethanolic extract of A. occidentale leaves in streptozotocin (STZ)-induced diabetic rats. Method Twenty-nine adult male Wistar rats were induced with DM intraperitoneally using a single dose of STZ (70 mg/kg). The STZ-induced rats were divided into groups and administered the same dose (100 mg/kg) of A. occidentale leaves extract and riboceine via gastric gavage at the dose (100 mg/kg) for seventeen days while metformin (40 mg/kg) was used as positive control. Fasting blood glucose and weight of the model rats were examined periodically. Activities of total protein, creatinine, urea, antioxidants (SOD, GSH and GPX), and level of serum insulin were determined. Expression of diabetes related genes including pancreas (Insulin, pdx-1, P16NK4A, and Mki-67), Liver (FAS, ACC, and GFAT) and KIM-1 genes were also determined. Results Data showed that treatment of STZ-induced diabetic rats with A. occidentale and riboceine at the same dose significantly ( p  
ISSN:2251-6581
2251-6581
DOI:10.1007/s40200-022-01165-2