Effects of eicosapentaenoic acid supplementation on heat shock protein 27, glycemic status and anthropometric indices in type 2 diabetes patients

Purpose Heat shock proteins (HSP-27) are reported to be involved in the pathophysiology of diabetes complications. The purpose of the current study is to assess the effects of eicosapentaenoic acid (EPA) supplementation on serum HSP-27, glycemic status and anthropometric indices in type 2 diabetes m...

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Bibliographic Details
Published in:Journal of diabetes and metabolic disorders 2022-12, Vol.22 (1), p.199-204
Main Authors: Ghaedi, Ehsan, Sharifdini, Javad Galyan, Javanbakht, Mohammad Hassan, Mohammadi, Hamed, Golzari, Mohammad Hassan, Zarei, Mahnaz, Hadi, Amir, Djalali, Mahmoud
Format: Article
Language:English
Subjects:
Analysis
Blood sugar
Diabetes
Endocrinology
Glycosylated hemoglobin
Heat shock proteins
Medicine
Medicine & Public Health
Metabolic Diseases
Omega-3 fatty acids
Proteins
Research Article
Type 2 diabetes
Unsaturated fatty acids
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Summary:Purpose Heat shock proteins (HSP-27) are reported to be involved in the pathophysiology of diabetes complications. The purpose of the current study is to assess the effects of eicosapentaenoic acid (EPA) supplementation on serum HSP-27, glycemic status and anthropometric indices in type 2 diabetes mellitus (T2DM) patients. Methods Thirty-six patients with T2DM were randomly allocated to obtain 2 g per day EPA (n = 18) or placebo (n = 18) for 8 weeks in a randomized, double-blind, placebo-controlled clinical trial. Fasting serum levels of HSP 27, fasting blood sugar, hemoglobin A1C, as well as anthropometric indices were measured. Results EPA supplementation reduces the serum level of HSP 27 in the EPA group compared with the placebo (P 
ISSN:2251-6581
2251-6581
DOI:10.1007/s40200-022-01083-3