Baicalin Alleviates Silica-Induced Lung Inflammation and Fibrosis by Inhibiting TLR4/NF-κB Pathway in Rats

Silicosis is an occupational lung disease caused by inhaling silica dust. The disease is characterized by early lung inflammation and late irreversible pulmonary fibrosis. Here we report the effect of Baicalin, a main flavonoid compound from the roots of Chinese herbal medicine Huang Qin on silicosi...

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Published in:Physiological research 2023-04, Vol.72 (Vol 72(2)), p.221-233
Main Authors: Zhang, Y, Liu, F, Jia, Q, Zheng, L, Tang, Q, Sai, L, Zhang, W, Du, Z, Peng, Ch, Bo, C, Zhang, F
Format: Article
Language:English
Subjects:
Actin
Alveoli
Apoptosis
Baicalin
Collagen
Collagen (type I)
Cytokines
E-cadherin
Fibrosis
Flavonoids
Herbal medicine
Inflammation
Interleukin 6
Lung diseases
Lungs
Medical research
NF-κB protein
Pathogenesis
Proteins
Pulmonary fibrosis
Silica
Silicosis
Smooth muscle
TLR4 protein
Toll-like receptors
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Vimentin
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Summary:Silicosis is an occupational lung disease caused by inhaling silica dust. The disease is characterized by early lung inflammation and late irreversible pulmonary fibrosis. Here we report the effect of Baicalin, a main flavonoid compound from the roots of Chinese herbal medicine Huang Qin on silicosis in a rat model. Results showed Baicalin (50 or 100 mg/kg/day) can mitigate the silica-induced lung inflammation and reduce the harm of alveolar structure and the blue region of collagen fibers in rat lung at 28 days after administration. At the same time, Baicalin also diminished the level of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1) in lung tissues. The protein expression of collagen I (Col-1), α-smooth muscle actin (α-SMA) and vimentin were down-regulated while E-cadherin (E-cad) was increased in Baicalin-treated rats. In addition, the Toll Like Receptor 4 (TLR4)/ nuclear factor kappaB (NF-κB) pathway was enabled at 28 days after silica infusion, and the treatment of Baicalin diminished the expression of TLR4 and NF-κB in the lungs of rat with silicosis. These results suggested that Baicalin inhibited the pulmonary inflammatory and fibrosis in a rat model of silicosis, which could be attributed to inhibition of the TLR4/NF-κB pathway.
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.934978