A timeline of cognitive functioning in glioma patients who undergo awake brain tumor surgery

• Published in: Acta neurochirurgica 2023-06, Vol.165 (6), p.1645-1653
• Main Authors: de Sain, A.M., Mantione, M.H.M., Wajer, I.M.C. Huenges, van Zandvoort, M.J.E., Willems, P.W.A., Robe, P.A., Ruis, C.
• Format: Article
• Language: English
• Subjects: Brain cancer; Brain Neoplasms - pathology; Brain tumors; Cognition; Cognitive ability; Craniotomy; Glioma; Glioma - complications; Glioma - pathology; Glioma - surgery; Humans; Interventional Radiology; Medicine; Medicine & Public Health; Minimally Invasive Surgery; Neurology; Neuroradiology; Neurosurgery; Original; Original Article; Short term memory; Surgery; Surgical Orthopedics; Wakefulness
• ISSN: 0942-0940; 0001-6268; 0942-0940
• DOI: 10.1007/s00701-023-05588-5

Background The purpose of awake brain tumor surgery is to maximize the resection of the tumor and to minimize the risk of neurological and cognitive impairments. The aim of this study is to gain understanding of the development of possible postoperative cognitive deficits after awake brain tumor surgery in patients with suspected gliomas, by comparing preoperative, early postoperative, and late postoperative functioning. A more detailed timeline will be helpful in informing candidates for surgery about what to expect regarding their cognitive functioning. Methods Thirty-seven patients were included in this study. Cognitive functioning was measured by means of a broad cognitive screener preoperatively, days after surgery and months after surgery in patients who underwent awake brain tumor surgery with cognitive monitoring. The cognitive screener included tests for object naming, reading, attention span, working memory, inhibition, inhibition/switching, and visuoperception. We performed a Friedman ANOVA to analyze on group level. Results Overall, no significant differences were found between preoperative cognitive functioning, early postoperative cognitive functioning, and late postoperative cognitive functioning, except for performances on the inhibition task. Directly after surgery, patients were significantly slower on this task. However, in the following months after surgery, they returned to their preoperative level. Conclusion The timeline of cognitive functioning after awake tumor surgery appeared overall stable in the early and late postoperative phase, except for inhibition, which is more difficult in the first days after awake brain tumor surgery. This more detailed timeline of cognitive functioning, in combination with future research, can possibly be contributing in informing patients and caregivers what to expect after awake brain tumor surgery.