Overview of phytosomes in treating cancer: Advancement, challenges, and future outlook

• Published in: Heliyon 2023-06, Vol.9 (6), p.e16561, Article e16561
• Main Authors: Gaikwad, Sachin S., Morade, Yogita Y., Kothule, Akshada M., Kshirsagar, Sanjay J., Laddha, Umesh D., Salunkhe, Kishor S.
• Format: Article
• Language: English
• Subjects: Cancer therapies; Herbal extract; Nanocarrier; Phytosomes; Review; Targeted drug delivery
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2023.e16561

One of the major causes of death on the globe is cancer. It has remained a significant obstacle for current therapies and has not yet been effectively treated. Conventional treatment strategies available for cancer such as surgery, chemotherapy, radiation therapy etc. have severe adverse effects. The use of herbal active constituents in cancer treatment has tremendous potential to increase the effectiveness of conventional cancer therapy. Natural plant active components have been reported to have strong in vitro pharmacological activity but narrow in vivo absorption. In order to increase their bioavailability and absorption and get around the drawbacks and negative effects of traditional herbal extracts, Phytosomes are one of the growing nanotechnologies that can be used to improve the miscibility of bioactive phytoconstituents in lipid-rich barriers and overcome their poor bioavailability. Many novel drug delivery carriers are employed for targeted delivery of phytoconstituent at the site of action. Phytosomes are well-known biocompatible nanocarriers that can be employed to increase the solubility and permeability of phytopharmaceuticals among various novel drug delivery systems (NDDS). This review mainly focused on various conventional as well as novel approaches and various Nano carrier used in cancer therapies. Also comprising summary of the most recent research on the development and use of phytosomes as a better carrier for herbal constituents in the treatment of cancer. Additionally provides information about the formulation, characterization technique and mechanism of drug release from phytosome. Some of the major herbal active constituents made of phytosome which have shown proven anticancer activity are also studied. Finally, challenges and future perspective related to phytosome in cancer treatment are also discussed. [Display omitted]