In vitro and in vivo assessment of the anti-inflammatory activity of olive leaf extract in rats

Inflammation is a complex and crucial process that protects the body against pathogens. Here in our study, we propose to scientifically justify the anti-inflammatory activity of olive leaf (OL). Initially, we ensured the safety of olive leaf extract (OLE) through acute oral administration of graded...

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Bibliographic Details
Published in:Inflammopharmacology 2023-06, Vol.31 (3), p.1529-1538
Main Authors: Fayez, Nada, Khalil, Waleed, Abdel-Sattar, Essam, Abdel-Fattah, Abdel-Fattah Mohamed
Format: Article
Language:English
Subjects:
Allergology
Animals
Anti-Inflammatory Agents
Biomedical and Life Sciences
Biomedicine
Carrageenan
Cyclooxygenase 2
Dermatology
Edema - chemically induced
Edema - drug therapy
Gastroenterology
Immunology
Inflammation - drug therapy
Interleukin-1 - adverse effects
Original
Original Article
Pharmacology/Toxicology
Plant Extracts
Plant Leaves
Rats
Rats, Wistar
Rheumatology
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Summary:Inflammation is a complex and crucial process that protects the body against pathogens. Here in our study, we propose to scientifically justify the anti-inflammatory activity of olive leaf (OL). Initially, we ensured the safety of olive leaf extract (OLE) through acute oral administration of graded doses up to 4 g\kg in Wistar rats. Thus, the extract was considered generally safe. We also evaluated the ability of the extract to reduce carrageenan-induced rat paw edema. Compared to diclofenac sodium (10 mg/kg PO), OLE showed significant ( P  
ISSN:0925-4692
1568-5608
DOI:10.1007/s10787-023-01208-x