Microbial production of nutraceuticals: Metabolic engineering interventions in phenolic compounds, poly unsaturated fatty acids and carotenoids synthesis

Nutraceuticals have attained substantial attention due to their health-boosting or disease-prevention characteristics. Growing awareness about the potential of nutraceuticals for the prevention and management of diseases affecting human has led to an increase in the market value of nutraceuticals in...

Full description

Saved in:
Bibliographic Details
Published in:Journal of food science and technology 2023-08, Vol.60 (8), p.2092-2104
Main Authors: Madhavan, Aravind, Arun, K. B., Alex, Deepthy, Anoopkumar, A. N., Emmanual, Shibitha, Chaturvedi, Preeti, Varjani, Sunita, Tiwari, Archana, Kumar, Vinod, Reshmy, R., Awasthi, Mukesh Kumar, Binod, Parameswaran, Aneesh, Embalil Mathachan, Sindhu, Raveendran
Format: Article
Language:English
Subjects:
Biotechnology
Carotenoids
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Diabetes
E coli
Enzymes
Fatty acids
Flavonoids
Food
Food Science
Functional foods & nutraceuticals
Genetic engineering
Industrial engineering
Laboratories
Manufacturing engineering
Market value
Metabolic engineering
Metabolism
Metabolites
Microorganisms
Nutrition
Phenols
Polyphenols
Polyunsaturated fatty acids
Prevention
Review
Review Article
Toxicology
Yeast
Zoology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nutraceuticals have attained substantial attention due to their health-boosting or disease-prevention characteristics. Growing awareness about the potential of nutraceuticals for the prevention and management of diseases affecting human has led to an increase in the market value of nutraceuticals in several billion dollars. Nevertheless, limitations in supply and isolation complications from plants, animals or fungi, limit the large-scale production of nutraceuticals. Microbial engineering at metabolic level has been proved as an environment friendly substitute for the chemical synthesis of nutraceuticals. Extensively used microbial systems such as E. coli and S. cerevisiae have been modified as versatile cell factories for the synthesis of diverse nutraceuticals. This review describes current interventions in metabolic engineering for synthesising some of the therapeutically important nutraceuticals (phenolic compounds, polyunsaturated fatty acids and carotenoids). We focus on the interventions in enhancing product yield through engineering at gene level or pathway level.
ISSN:0022-1155
0975-8402
DOI:10.1007/s13197-022-05482-5