Lower HLA-G levels in extravillous trophoblasts of human term placenta in gestational diabetes mellitus than in normal controls

The non-classical human leucocyte antigen (HLA) class I molecule HLA-G is widely known to play a major role in feto-maternal tolerance. We tested the hypothesis that HLA-G expression is altered in placentas of women with gestational diabetes mellitus (GDM) in a specific pattern that depends on fetal...

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Published in:Histochemistry and cell biology 2023-06, Vol.159 (6), p.527-535
Main Authors: Knabl, Julia, Hüttenbrenner, Rebecca, Mahner, Sven, Kainer, Franz, Desoye, Gernot, Jeschke, Udo
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell number
Cell surface
Decidua
Developmental Biology
Diabetes mellitus
Diabetes, Gestational - metabolism
Female
Fetuses
Gestational diabetes
Histocompatibility antigen HLA
HLA-G Antigens - metabolism
Humans
Immunofluorescence
Immunohistochemistry
Immunological tolerance
Placenta - metabolism
Pregnancy
Short Communication
Trophoblasts
Trophoblasts - metabolism
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Summary:The non-classical human leucocyte antigen (HLA) class I molecule HLA-G is widely known to play a major role in feto-maternal tolerance. We tested the hypothesis that HLA-G expression is altered in placentas of women with gestational diabetes mellitus (GDM) in a specific pattern that depends on fetal sex. HLA-G expression was analysed in a total of 80 placentas (40 placentas from women with GDM and 40 healthy controls) by immunohistochemistry using the semi-quantitative immunoreactive score (IRS). Double immunofluorescence staining identified the cells expressing HLA-G in the decidua and allowed evaluation of the expression pattern. We found a significant ( p  
ISSN:0948-6143
1432-119X
DOI:10.1007/s00418-022-02163-4